Ipertensione e Fisiopatologia Nefro-Cardio-Metabolica (G. Cerasola)

Unità di Ricerca: Direttore Cattedra e Scuola di Specializzazione di Malattie dell’Apparato Cardiovascolare, Università degli Studi di Palermo e U.O.C. di Cardiologia e Riabilitazione Cardiovascolare, Centro di Riferimento Regionale per la Diagnosi e Cura dell’Insufficienza Cardiaca e per il Trattamento dell’Ipertensione Polmonare e Centro per la Diagnosi Precoce di Aterosclerosi Preclinica e Pluridistrettuale e per la Prevenzione Secondaria,

Coordinatore: Prof.ssa Giuseppina Novo

Sede Universitaria: Università di Palermo, Dipartimento universitario di Scienze per la Promozione della Salute (PROSAMI), Università degli Studi di Palermo; Dipartimento assistenziale di Emergenza-Urgenza, A.O.U.Policlinico “Paolo Giaccone” di Palermo.

Indirizzo: Via del Vespro n. 129 – 90127 – Palermo

Tel.: 091- 6557016- 0916554303

Afferenti Unità di ricerca con qualifica

Dott.ssa Corrado Egle – Ricercatore Confermato
Evola Giovanna – Dirigente Medico di I livello
Manzullo Nilla – Dirigente Medico di I livello
Triolo Fabio- Dirigente medico I livello
Di Lisi Daniela- Dirigente medico I livello
Lunetta Monica – Dirigente medico I livello
Prof. Salvatore  Novo – Prof Ordinario in congedo

PRINCIPALI TEMI DI RICHIESTA

 CARDIO-ONCOLOGIA:

• Individuazione precoce del danno cardiaco (mediante speckle tracking echocardiography) e vascolare (mediante arterial stiffness) in pazienti trattati con farmaci antineoplastici: antracicline, immunoterapia, TKI
• Utilità dell’esercizio nel limitare il danno cardiovascolare in pazienti con K mammella sottoposte a chemioterapia (controllo con test cardiopolmonare)

Principali pubblicazioni prodotte in tale ambito:

• Sex differences in anthracycline-induced cardiotoxicty: the benefits of estrogens.
  Cadeddu Dessalvi C¹, Pepe A², Penna C³, Gimelli A⁴, Madonna R⁵, Mele D⁶, Monte I⁷, Novo G⁸, Nugara C⁸, Zito C⁹, Moslehi JJ¹⁰, de Boer RA¹¹, Lyon AR¹², Tocchetti CG^13,14, Mercuro G¹. Heart Fail Rev. 2019 Jun 29. doi: 10.1007/s10741-019-09820-2.
• An update on the conquests and perspectives of cardio-oncology in the field of tumor angiogenesis-targeting TKI-based therapy.
  Galvano A, Guarini A, Iacono F, Castiglia M, Rizzo S, Tarantini L, Gori S, Novo G, Bazan V, Russo A. Expert Opin Drug Saf. 2019 Jun;18(6):485-496. doi: 10.1080/14740338.2019.1613371. Epub 2019 May 7. Review.
• Arterial hypertension in cancer: The elephant in the room.
  Tini G, Sarocchi M, Tocci G, Arboscello E, Ghigliotti G, Novo G, Brunelli C, Lenihan D, Volpe M, Spallarossa P. Int J Cardiol. 2019 Apr 15;281:133-139. doi: 10.1016/j.ijcard.2019.01.082. Epub 2019 Jan 28.
• Cardiotoxicity mechanisms of the combination of BRAF-inhibitors and MEK-inhibitors.
  Bronte E, Bronte G, Novo G, Rinaldi G, Bronte F, Passiglia F, Russo A. Pharmacol Ther. 2018 Dec;192:65-73. doi: 10.1016/j.pharmthera.2018.06.017. Epub 2018 Jun 28. Review.
• Antineoplastic Drug-Induced Cardiotoxicity: A Redox Perspective.
  Varricchi G, Ameri P, Cadeddu C, Ghigo A, Madonna R, Marone G, Mercurio V, Monte I, Novo G, Parrella P, Pirozzi F, Pecoraro A, Spallarossa P, Zito C, Mercuro G, Pagliaro P, Tocchetti CG. Front Physiol. 2018 Mar 7;9:167. doi: 10.3389/fphys.2018.00167. eCollection 2018. Review.
• Anticancer therapy-induced vascular toxicity: VEGF inhibition and beyond.
  Di Lisi D, Madonna R, Zito C, Bronte E, Badalamenti G, Parrella P, Monte I, Tocchetti CG, Russo A, Novo G. Int J Cardiol. 2017 Jan 15;227:11-17. doi: 10.1016/j.ijcard.2016.11.174. Epub 2016 Nov 9. Review.
• A recommended practical approach to the management of target therapy and angiogenesis inhibitors cardiotoxicity: an opinion paper of the working group on drug cardiotoxicity and cardioprotection, Italian Society of Cardiology.
  Maurea N, Spallarossa P, Cadeddu C, Madonna R, Mele D, Monte I, Novo G, Pagliaro P, Pepe A, Tocchetti CG, Zito C, Mercuro G. J Cardiovasc Med (Hagerstown). 2016 May;17 Suppl 1 Special issue on Cardiotoxicity from Antiblastic Drugs and Cardioprotection:e93-e104. Review.
• A recommended practical approach to the management of anthracycline-based chemotherapy cardiotoxicity: an opinion paper of the working group on drug cardiotoxicity and cardioprotection, Italian Society of Cardiology.
  Spallarossa P, Maurea N, Cadeddu C, Madonna R, Mele D, Monte I, Novo G, Pagliaro P, Pepe A, Tocchetti CG, Zito C, Mercuro G. J Cardiovasc Med (Hagerstown). 2016 May;17 Suppl 1 Special issue on Cardiotoxicity from Antiblastic Drugs and Cardioprotection:e84-e92. Review.
• Cardiovascular imaging in the diagnosis and monitoring of cardiotoxicity: cardiovascular magnetic resonance and nuclear cardiology.
  Pepe A, Pizzino F, Gargiulo P, Perrone-Filardi P, Cadeddu C, Mele D, Monte I, Novo G, Zito C, Di Bella G. J Cardiovasc Med (Hagerstown). 2016 May;17 Suppl 1 Special issue on Cardiotoxicity from Antiblastic Drugs and Cardioprotection:e45-e54. Review.
• Cardiovascular imaging in the diagnosis and monitoring of cardiotoxicity: role of echocardiography.
  Zito C, Longobardo L, Cadeddu C, Monte I, Novo G, Dell’Oglio S, Pepe A, Madonna R, Tocchetti CG, Mele D. J Cardiovasc Med (Hagerstown). 2016 May;17 Suppl 1 Special issue on Cardiotoxicity from Antiblastic Drugs and Cardioprotection:e35-e44. Review.
• Role of biomarkers in monitoring antiblastic cardiotoxicity.
  Novo G, Cadeddu C, Sucato V, Pagliaro P, Romano S, Tocchetti CG, Zito C, Longobardo L, Nodari S, Penco M. J Cardiovasc Med (Hagerstown). 2016 May;17 Suppl 1 Special issue on Cardiotoxicity from Antiblastic Drugs and Cardioprotection:e27-e34. Review.
• Pathophysiology of anthracycline cardiotoxicity. Mele D, Tocchetti CG, Pagliaro P, Madonna R, Novo G, Pepe A, Zito C, Maurea N, Spallarossa P. J Cardiovasc Med (Hagerstown). 2016 May;17 Suppl 1 Special issue on Cardiotoxicity from Antiblastic Drugs and Cardioprotection:e3-e11. Review.
• A recommended practical approach to the management of target therapy and angiogenesis inhibitors cardiotoxicity: an opinion paper of the working group on drug cardiotoxicity and cardioprotection, Italian Society of Cardiology.
  Maurea N, Spallarossa P, Cadeddu C, Madonna R, Mele D, Monte I, Novo G, Pagliaro P, Pepe A, Tocchetti CG, Zito C, Mercuro G. J Cardiovasc Med (Hagerstown). 2016 May;17 Suppl 1:S93-S104. doi: 10.2459/JCM.0000000000000383. Review.
• A recommended practical approach to the management of anthracycline-based chemotherapy cardiotoxicity: an opinion paper of the working group on drug cardiotoxicity and cardioprotection, Italian Society of Cardiology.
  Spallarossa P, Maurea N, Cadeddu C, Madonna R, Mele D, Monte I, Novo G, Pagliaro P, Pepe A, Tocchetti CG, Zito C, Mercuro G. J Cardiovasc Med (Hagerstown). 2016 May;17 Suppl 1:S84-92. doi: 10.2459/JCM.0000000000000381. Review.
• Cardiovascular imaging in the diagnosis and monitoring of cardiotoxicity: role of echocardiography.
  Zito C, Longobardo L, Cadeddu C, Monte I, Novo G, Dell’Oglio S, Pepe A, Madonna R, Tocchetti CG, Mele D. J Cardiovasc Med (Hagerstown). 2016 May;17 Suppl 1:S35-44. doi: 10.2459/JCM.0000000000000374. Review.
• Pathophysiology of anthracycline cardiotoxicity.
  Mele D, Tocchetti CG, Pagliaro P, Madonna R, Novo G, Pepe A, Zito C, Maurea N, Spallarossa P. J Cardiovasc Med (Hagerstown). 2016 May;17 Suppl 1:S3-S11. doi: 10.2459/JCM.0000000000000378. Review.

TAKOTSUBO

Collaborazione multicentrica per valutazione epidemioligica, prognostica e terapeutica

Principali pubblicazioni prodotte in tale ambito:

• Incidence and Clinical Impact of Recurrent Takotsubo Syndrome: Results From the GEIST Registry.
  El-Battrawy I, Santoro F, Stiermaier T, Möller C, Guastafierro F, Novo G, Novo S, Mariano E, Romeo F, Ro meo F, Thiele H, Guerra F, Capucci A, Giannini I, Brunetti ND, Eitel I, Akin I. J Am Heart Assoc. 2019 May 7;8(9):e010753. doi: 10.1161/JAHA.118.010753.
• Long-term outcome in patients with Takotsubo syndrome presenting with severely reduced left ventricular ejection fraction.
  Citro R, Radano I, Parodi G, Di Vece D, Zito C, Novo G, Provenza G, Bellino M, Prota C, Silverio A, Antonini-Canterin F, Rigo F, Vriz O, Galasso G, Bossone E, Salerno-Uriarte J,Piscione F. Eur J Heart Fail. 2019 Jun;21(6):781-789. doi: 10.1002/ejhf.1373. Epub 2019 Feb
• Prevalence and Prognostic Impact of Diabetes in Takotsubo Syndrome: Insights From the International, Multicenter GEIST Registry.
  Stiermaier T, Santoro F, El-Battrawy I, Möller C, Graf T, Novo G, Santangelo A, Mariano E, Romeo F, Caldarola P, Fanelli M, Thiele H, Brunetti ND, Akin I, Eitel I. Diabetes Care. 2018 May;41(5):1084-1088. doi: 10.2337/dc17-2609. Epub 2018 Feb 15.
• Characteristics of coronary microcirculatory function in patients with Takotsubo syndrome.
  Novo G, Quagliana A, Buccheri D, Rizzo S, Giambanco S, Giambanco F, Evola S, Geraci G, Novo S. J Thorac Dis. 2017 Nov;9(11):4531-4537. doi: 10.21037/jtd.2017.10.93.
• Risk Stratification Using the CHA₂DS₂-VASc Score in Takotsubo Syndrome: Data From the Takotsubo Italian Network.
  Parodi G, Scudiero F, Citro R, Silverio A, Bellandi B, Zito C, Antonini-Canterin F, Rigo F, Zocchi C, Bossone E, Salerno-Uriarte J, Piscione F, Mario CD; Takotsubo Italian Network (TIN). J Am Heart Assoc. 2017 Sep 14;6(9). pii: e006065. doi: 10.1161/JAHA.117.006065.
• From Molecular Mechanisms to Clinical Management of Antineoplastic Drug-Induced Cardiovascular Toxicity: A Translational Overview.
  Tocchetti CG, Cadeddu C, Di Lisi D, Femminò S, Madonna R, Mele D, Monte I, Novo G, Penna C, Pepe A, Spallarossa P, Varricchi G, Zito C, Pagliaro P, Mercuro G. Antioxid Redox Signal. 2019 Jun 20;30(18):2110-2153. doi: 10.1089/ars.2016.6930. Epub 2017 May 15.
• Climatic variables in Takotsubo cardiomyopathy: role of temperature.
  Novo G, Mariano E, Giambanco S, Bonomo V, Manno G, Viele A, Evola S, Giambanco F, Assennato P, Novo S, Romeo F. J Cardiovasc Med (Hagerstown). 2017 Mar;18(3):165-169. doi: 10.2459/JCM.0000000000000369.
• Independent Impact of RV Involvement on In-Hospital Outcome of Patients With Takotsubo Syndrome. Citro R, Bossone E, Parodi G, Rigo F, Nardi F, Provenza G, Zito C, Novo G, Vitale G, Prota C, Silverio A, Vriz O, D’Andrea A, Antonini-Canterin F, Salerno-Uriarte J, Piscione F; Tako-tsubo Italian Network Investigators. JACC Cardiovasc Imaging. 2016 Jul;9(7):894-895. doi: 10.1016/j.jcmg.2015.06.005. Epub 2015 Sep 9. No abstract available.

MICARDITI

Ruolo dell’ecocardiografia speckle tracking e della risonanza magnetica cardiaca nella diagnosi e prognosi delle miocarditi

Principali pubblicazioni prodotte in tale ambito:

SCOMPENSO CARDIACO

• Ruolo della telemedicina nello scompenso cardiaco a FE ridotta
• Nuovi marcatori ecocardiografici di rischio aritmico in pazienti con scompenso cardiaco ad FE ridotta e mid range
• Ruolo dell’eco stress fisico nella diagnosi di scompenso cardiaco ad FE preservata
• Ruolo dell’empaglifozin nei pazienti con scompenso cardiaco

Principali pubblicazioni prodotte in tale ambito:

• Early Effects of Sacubitril/Valsartan on Exercise Tolerance in Patients with Heart Failure with Reduced Ejection Fraction.
  Vitale G, Romano G, Di Franco A, Caccamo G, Nugara C, Ajello L, Storniolo S, Sarullo S, Agnese V, Giallauria F, Novo G, Clemenza F, Sarullo FM. J Clin Med. 2019 Feb 20;8(2). pii: E262. doi: 10.3390/jcm8020262.

CARDIOPATIA ISCHEMICA

Nuovi parametri ecocardiografici valutati durante stress eco in pazienti con cardiopatia ischemica

Principali pubblicazioni prodotte in tale ambito:

• Quality control of B-lines analysis in stress Echo 2020.
  Scali MC, Ciampi Q, Picano E, Bossone E, Ferrara F, Citro R, Colonna P, Costantino MF, Cortigiani L, Andrea A, Severino S, Dodi C, Gaibazzi N, Galderisi M, Barbieri A, Monte I, Mori F, Reisenhofer B, Re F, Rigo F, Trambaiolo P, Amor M, Lowenstein J, Merlo PM, Daros CB, de Castro E Silva Pretto JL, Miglioranza MH, Torres MAR, de Azevedo Bellagamba CC, Chaves DQ, Simova I, Varga A, Čelutkienė J, Kasprzak JD, Wierzbowska-Drabik K, Lipiec P, Weiner-Mik P, Szymczyk E, Wdowiak-Okrojek K, Djordjevic-Dikic A, Dekleva M, Stankovic I, Neskovic AN, Zagatina A, Di Salvo G, Perez JE, Camarozano AC, Corciu AI, Boshchenko A, Lattanzi F, Cotrim C, Fazendas P, Haberka M, Sobkowic B, Kosmala W, Witkowski T, Gosciniak P, Salustri A, Rodriguez-Zanella H, Leal LIM, Nikolic A, Gligorova S, Urluescu ML, Fiorino M, Novo G, Preradovic-Kovacevic T, Ostojic M, Beleslin B, Villari B, De Nes M, Paterni M, Carpeggiani C; Stress Echo 2020 study group of the Italian Society of Echocardiography and Cardiovascular Imaging (SIECVI). Cardiovasc Ultrasound. 2018 Sep 25;16(1):20. doi: 10.1186/s12947-018-0138-7.

CORRELAZIONE TRA ATEROSCLEROSI PRECLINICA E RISCHIO CARDIOVASCOLARE:

 Principali pubblicazioni prodotte in tale ambito:

• Impact of preclinical carotid atherosclerosis on global cardiovascular risk stratification and events in a 10-year follow-up: comparison between the algorithms of the Framingham Heart Study, the European SCORE and the Italian ‘Progetto Cuore’.
  Novo S, Carità P, Lo Voi A, Muratori I, Tantillo R, Corrado E, Kalodiki E, Novo G. J Cardiovasc Med (Hagerstown). 2019 Feb;20(2):91-96. doi: 10.2459/JCM.0000000000000740.
• The association between coronary microvascular dysfunction and carotid intima media thickness in patients with cardiac syndrome X.
  Sucato V, Evola S, Novo G, Corrado E, Coppola G, Andolina G, Assennato P, Novo S. Int J Cardiol. 2016 Jul 1;214:383-6. doi: 10.1016/j.ijcard.2016.04.028. Epub 2016 Apr 7.

INSULINO RESISTENZA E RISCHIO CARDIOVASCOLARE

• Long-term parameters of heart rate variability in patients with insulin-resistance.
  Novo G, Manno G, Levantino P, Cangemi S, Evola V, Vitale G, Evola S, Luparelli M, Novo S.
  J Cardiovasc Med (Hagerstown). 2019 Apr 29. doi: 10.2459/JCM.0000000000000798. [Epub ahead of print]
• Impact of insulin resistance on cardiac and vascular function.
  Novo G, Manno G, Russo R, Buccheri D, Dell’Oglio S, Morreale P, Evola G, Vitale G, Novo S. Int J Cardiol. 2016 Oct 15;221:1095-9. doi: 10.1016/j.ijcard.2016.07.087. Epub 2016 Jul 10.
• Impact of insulin resistance on cardiac and vascular function.
  Novo G, Manno G, Russo R, Buccheri D, Dell’Oglio S, Morreale P, Evola G, Vitale G, Novo S. Int J Cardiol. 2016 Oct 15;221:1095-9. doi: 10.1016/j.ijcard.2016.07.087. Epub 2016 Jul 10.
• Early subclinical ventricular dysfunction in patients with insulin resistance.
  Novo G, Pugliesi M, Visconti C, Spatafora P, Fiore M, Di Miceli R, Guarneri FP, Vitale G, Novo S. J Cardiovasc Med (Hagerstown). 2014 Feb;15(2):110-4. doi: 10.2459/JCM.0b013e3283638164.
  PMID: 24522082
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  Select item 20466373
• Insulin resistance and acute coronary syndrome.
  Caccamo G, Bonura F, Bonura F, Vitale G, Novo G, Evola S, Evola G, Grisanti MR, Novo S. Atherosclerosis. 2010 Aug;211(2):672-5. doi: 10.1016/j.atherosclerosis.2010.03.033. Epub 2010 Apr 4.