Cardiologia e Fisiopatologia Cardiovascolare (G. Ambrosio)

Aggiornamento Ottobre 2015

Unità di Ricerca:
Fisiopatologia Cardiovascolare

Responsabile:
Prof. Giuseppe Ambrosio
Università degli Studi di Perugia
Dipartimento di Medicina,Sezione di Cardiologia e Fisiopatologia Cardiovascolare
Ospedale S. Maria della Misericordia
Piazzale Menghini
06156 Perugia
tel: 075 5271509
fax: 075 5271244
e-mail: giuseppe.ambrosio@ospedale.perugia.it

Linee di ricerca:
Ischemia miocardica acuta
Cardiopatia ischemica cronica
Miocardio “stordito” e “ibernato”
Scompenso cardiaco
Meccanismi del danno miocardico da riperfusione post-ischemica
Fisiopatologia dello stress ossidativo
Interazione tra piastrine,neutrofili,ed endotelio
Fisiopatologia del microciclo

Laboratori/strumentazione:

Videomicroscopia Intravitale Microscopio per videomicroscopia intravitale;

Lampade luce riflessa, stroboscopica, xenon;

Sistema per la misurazione di parametri emodinamici nell’animale (Mclab);

Sistema elaborazione dati video;

Cauterizzatore

Valutazione della funzione cardiaca e vascolare vascolare Ecografo vascolare;

Sistema Endopat;

Flussimetro Transonic;

Tonometro sphygmocor;

Sonda ecografica ultraband;

Sistema automatico di analisi dell’immagine ecocardiografica

Collaborazioni internazionali:

La nostra Sezione di Cardiologia e Fisiopatologia Cardiovascolare è:

– Gemellata con la Division of Cardiology, Johns Hopkins School of Medicine, Baltimore, MD, U.S.A., Accordo-Quadro bilaterale di formazione professionale e ricerca scientifica

– Gemellata con l’Instituto Cardiologico “Alberto C. Taquini”, Università di Buenos Aires, Argentina, Accordo-Quadro bilaterale di formazione professionale e ricerca scientifica

– Gemellata con l’Hospital Italiano di Buenos Aires, Argentina, Accordo-Quadro bilaterale di formazione professionale e ricerca scientifica

Publicazioni del triennio 2013-2015:

Tritto I, Zuchi C, Vitale S, Ambrosio G Therapy against reperfusion-induced microvascular injury Current Pharmaceutical Design 19:4586-96, 2013

Moreo A, Ambrosio G, De Chiara B, Tran T, Raman SV Influence of midwall fibrosis on diastolic dysfunction in non-ischemic cardiomyopathy International Journal of Cardiology 163:342-4, 2013

Lanza GA, Camici PG, Galiuto L, Niccoli G, Pizzi C, Di Monaco A, Sestito A, Novo S, Piscione F, Tritto I, Ambrosio G, Bugiardini R, Crea F, Marzilli M; on behalf of the ‘Gruppo di Studio di Fisiopatologia Coronarica e Microcircolazione’, Società Italiana di Cardiologia Methods to investigate coronary microvascular function in clinical practice Journal of Cardiovascular Medicine 14:1-18, 2013

Zuchi C, Tritto I, Ambrosio G. Angina pectoris in women: Focus on microvascular disease. International Journal of Cardiology, 163:132-40, 2013

Guerri-Guttenberg RA, Castilla R, Francos GC, Müller A, Ambrosio G, Milei J.Transforming Growth Factor β1 and Coronary Intimal Hyperplasia in Pediatric Patients With Congenital Heart Disease Canadian Journal of Cardiolology 29:849-57 2013

Borghi C, Ambrosioni E, Omboni S, Cicero AF, Bacchelli S, Esposti DD, Vinereanu D, Ambrosio G, Zava D. Zofenopril and ramipril and acetylsalicylic acid in postmyocardial infarction patients with left ventricular systolic dysfunction: a retrospective analysis in hypertensive patients of the SMILE-4 study Journal of  Hypertension 31:1256-64, 2013

Morici N, Savonitto S, Murena E, Antonicelli R, Piovaccari G, Tucci D, Tamburino C, Fontanelli A, Bolognese L, Menozzi M, Cavallini C, Petronio AS, Ambrosio G, Piscione F, Steffenino G, De Servi S Causes of Death in Patients ≥75 Years of Age With Non-ST-Segment Elevation Acute Coronary Syndrome.American Journal of Cardiology 112:1-7, 2013

Carluccio E, Dini FL, Biagioli P, Lauciello R, Simioniuc A, Zuchi C, Alunni G, Reboldi G, Marzilli M, Ambrosio G. The ‘Echo Heart Failure Score’: an echocardiographic risk prediction score of mortality in systolic heart failure European Journal of Heart Failure 15:868-76, 2013

Quercioli A, Montecucco F, Pataky Z, Thomas A, Ambrosio G, Staub C, Di Marzo V, Ratib O, Mach F, Golay A, Schindler TH Improvement in coronary circulatory function in morbidly obese individuals after gastric bypass-induced weight loss: relation to alterations in endocannabinoids and adipocytokines European Heart Journal 34:2063-73 2013

Borghi C, Ambrosioni E, Omboni S, Cicero AF, Bacchelli S, Esposti DD, Novo S, Vinereanu D, Ambrosio G, Reggiardo G, Zava D. Cost-effectiveness of zofenopril in patients with left ventricular systolic dysfunction after acute myocardial infarction: a post hoc analysis of SMILE-4.Clinicoeconomic Outcomes Research 5:317-25, 2013

Gehring M, Taylor RS, Mellody M, Casteels B, Piazzi A, Gensini G, Ambrosio G Factors influencing clinical trial site selection in Europe: the Survey of Attitudes towards Trial sites in Europe (the SAT-EU Study). British Medical Journal Open 2013 Nov 15;3(11):e002957. doi: 10.1136/bmjopen-2013-002957

Chang H, Tran T, Billman GE, Julian MW, Hamlin RL, Simonetti OP, Ambrosio G, Baker PB 3rd, Shao G, Crouser ED, Raman SV At-risk but viable myocardium in a large animal model of non ST-segment elevation acute coronary syndrome: cardiovascular magnetic resonance with ex vivo validation Journal of  Cardiovascular Magnetic Resonance 15:94, 2013

Verdecchia P, Reboldi G, Di Pasquale G, Mazzotta G, Ambrosio G, Yang S, Pogue J, Wallentin L, Ezekowitz MD, Connolly SJ, Yusuf S; the RE-LY Study Investigators. Prognostic Usefulness of Left Ventricular Hypertrophy by Electrocardiography in Patients With Atrial Fibrillation (from the Randomized Evaluation of Long-Term Anticoagulant Therapy Study) American Journal of  Cardiology 113:669-75, 2014

Valenta I, Dilsizian V, Quercioli A, Jüngling FD, Ambrosio G, Wahl R, Schindler TH. Impact of obesity and bariatric surgery on metabolism and coronary circulatory function. Current Cardiology Reports 16:433, 2014

Cardona A, Ambrosio G, Mengoni A, D’Antonio A, Bentivoglio M, Milei J, Angeli F. Pulse pressure affects the relationship between flow-mediated dilatation and cardiovascular risk. International Journal of Cardiology 175:579-581, 2014

Schindler TH, Quercioli A, Valenta I, Ambrosio G, Wahl RL, Dilsizian V. Quantitative Assessment of Myocardial Blood Flow-Clinical and Research Applications. Seminars in Nuclear Medicine 44:274-293, 2014

Parissis JT, Andreoli C, Kadoglou N, Ikonomidis I, Farmakis D, Dimopoulou I, Iliodromitis E, Anastasiou-Nana M, Lainscak M, Ambrosio G, Mebazaa A, Filippatos G, Follath F.

Differences in clinical characteristics, management and short-term outcome between acute heart failure patients chronic obstructive pulmonary disease and those without this co-morbidity. Clinical Research in Cardiology 103:733-41, 2014

Parissis JT, Farmakis D, Andreoli C, Rafouli-Stergiou P, Ambrosio G, Anastasiou-Nana M, Filippatos G. Cardio-reno-hepatic interactions in acute heart failure: the role of γ-glutamyl transferase International Journal of Cardiology 173:556-7, 2014

Held C, Tricoci P, Huang Z, Van de Werf F, White HD, Armstrong PW, Ambrosio G, Aylward PE, Moliterno DJ, Wallentin L, Chen E, Erkan A, Jiang L, Strony J, Harrington RA, Mahaffey KW. Vorapaxar, a platelet thrombin-receptor antagonist, in medically managed patients with non-ST-segment elevation acute coronary syndrome: results from the TRACER trial European Heart Journal –  Acute Cardiovascular Care 3:246-56, 2014

Mazzeschi C, Piana N,  Capezzali D, Mommi A, Aiello C, Gatti M, Romani G, Buratta L, Battistini D, Nasini G, Reginato E, Urbani L, Pazzagli C, Ferri C, Ambrosio G, De Feo P. The Impact of Strenuous Group Physical Activity on Mood States, Personal Views, Body Composition, and Markers of Myocardial Damage in Overweight/Obese Adults: The ‘‘Step-by-Step Italy’s Coast to Coast’’ Trek BioMed Research International, 2014

Weisel RD, Nussmeier N, Newman MF, Pearl RG, Wechsler AS, Ambrosio G, Pitt B, Clare RM, Pieper KS, Mongero L, Reece TL, Yau TM, Fremes S, Menasché P, Lira A, Harrington RA, Ferguson TB, and the RED-CABG Executive and Steering Committees  Predictors of Contemporary CABG Outcomes. Journal of Thoracic and Cardiovascular Surgery 148:2720-2726, 2014

Castilla R, Cao G, Frers RK, Müller A, Ambrosio G, Milei J.Inverse expression of estrogen receptor alpha and apolipoprotein B in coronary intimal hyperplasia of surgically repaired congenital heart disease: A pre-atherosclerotic condition?International Journal of  Cardiology 177:548-50, 2014

Angeli F, Verdecchia P, Savonitto S, Arraiz G, Zaninotto M, Broccatelli A, Cosma C, De Servi S, Sabino F, Briguori C, Ambrosio G, Cavallini C. Cystatin C and risk of mortality among patients undergoing percutaneous coronary intervention. EuroIntervention 2014

Senni M, Paulus WJ, Gavazzi A, Fraser AG, Díez J, Solomon SD, Smiseth OA, Guazzi M, Lam CS, Maggioni AP, Tschöpe C, Metra M, Hummel SL, Edelmann F, Ambrosio G, Coats AJS, Filippatos GS, Gheorghiade M, Anker SD, Levy D, Pfeffer MA, Stough WG, Pieske BM

New strategies for heart failure with preserved ejection fraction: the importance of targeted therapies for heart failure phenotypes European Heart Journal 35:2797-815, 2014

Ambrosio G, Savino K.CMR Assessment of Microvascular Obstruction in STEMI: Ready for Prime Time?Journal of the American College of Cardiology:64;1227-30, 2014

Gehring M, Jommi C, Tarricone R, Cirenei M, Ambrosio G, (The Italian SAT-EU Study Group).Towards a More Competitive Italy in Clinical Research: The Survey of Attitudes towards Trial sites in Europe (The SAT-EU StudyTM). Epidemiology, Biostatistics and Public Health, 2014

Cardona A, Kondapally Seshasai SR, Davey J, Arrebola-Moreno AL, Ambrosio G, Kaski JC, Ray KK. A meta-analysis of published studies of endothelial dysfunction does not support its routine clinical use International Journal of Clinical Practice 69:649–658, 2015

Lip GY, Rushton-Smith SK, Goldhaber SZ, Fitzmaurice DA, Mantovani LG, Goto S, Haas S, Bassand JP, Camm AJ, Ambrosio G, Janský P, Mahmeed WA, Oh S, van Eickels M, Raatikainen P, Steffel J, Oto A, Kayani G, Accetta G, Kakkar AK; for the GARFIELD-AF Investigators. Does Sex Affect Anticoagulant Use for Stroke Prevention in Nonvalvular Atrial Fibrillation? The Prospective Global Anticoagulant Registry in the FIELD-Atrial Fibrillation. Circulation – Cardiovascular Quality Outcomes: 8(Suppl 1):S12-20, 2015

Otero-Losada M, Cao G, González J, Muller A, Ottaviano G, Lillig C, Capani F, Ambrosio G, Milei J.  Functional and Morphological Changes in Endocrine Pancreas following Cola Drink Consumption in Rats. PLoS One 2015 Mar 19;10(3):e0118700. doi: 10.1371/journal.pone.0118700

Vagnarelli F, Corsini A, Bugani G, Lorenzini M, Longhi S, Bacchi Reggiani ML, Biagini E, Graziosi M, Cinti L, Norscini G, Taglieri N, Semprini F, Nanni S, Pasquale F, Rocchi G, Melandri G, Ambrosio G, Rapezzi C. Troponin T elevation in acute aortic syndromes: Frequency and impact on diagnostic delay and misdiagnosis. European Heart Journal Acute Cardiovascular Care 2015. Camm AJ, Manolis A, Ambrosio G, Daly C, Komajda M, Lopez de Sa E, Lopez-Sendon JL, Mugelli A, Muggli F, Tamargo J. Unresolved issues in the management of chronic stable angina. International Journal of Cardiology 201:200-207, 2015

Reyes LA, Boslett J, Varadharaj S, De Pascali F, Hemann C, Druhan LJ, Ambrosio G, El-Mahdy M, Zweier JL. Depletion of NADP(H) due to CD38 activation triggers endothelial dysfunction in the postischemic heart. Proceedings of the National Academy of Sciences U S A. 2015

Borghi C, Omboni S, Cicero AF, Bacchelli S, Degli Esposti D, Novo S, Vinereanu D, Ambrosio G, Ambrosioni E. Randomised comparison of zofenopril and ramipril plus acetylsalicylic acid in postmyocardial infarction patients with left ventricular systolic dysfunction: a post hoc analysis of the SMILE-4 Study in patients according to levels of left ventricular ejection fraction at entryBritish Medical Journal Open Heart. 2015 Aug 3;2(1):e000195. doi: 10.1136/openhrt-2014-000195.