Dipartimento di Medicina Specialistica Diagnostica e Sperimentale (DIEMS) – Sezione di Cardiologia

Unità di Ricerca: CARDIOLOGIA CLINICA 
Responsabile/Coordinatore: Prof. Raffaele Bugiardini (Professore Ordinario Malattie dell’Apparato Cardiovascolare SSD: MED/11)
Sede Universitaria: Università di Bologna, Dipartimento di Medicina Specialistica Diagnostica e Sperimentale (DIMES) – Sezione di Cardiologia

Indirizzo: Via Massarenti 9, c/o Policlinico S.Orsola-Malpighi – Padiglione 11, 40138, Bologna (BO)

Tel: +39 051347290

Fax: +39 051347290

E-mail: raffaele.bugiardini@unibo.it

Sito web: https://www.unibo.it/sitoweb/raffaele.bugiardini

Sito web: http://www.dimes.unibo.it/it/servizi-e-strutture/laboratori/area-specialistica/as_08laboratorio-di-epidemiologia-e-cardiologia-clinica

Sito web: http://www.dimes.unibo.it/it/ricerca/angiologia-cardiologia-ecardiochirurgia/cardiologia-ii/cardiomiopatia-ischemica

Linee di ricerca:

  • Cardiopatia ischemica cronica e acuta
  • Funzione endoteliale
  • Vasospasmo coronarico e microcircolazione coronarica
  • Registri clinici cardiovascolari
  • Malattia coronarica e donna: differenze di genere e di sesso
  • Differenze di genere e di sesso nella diagnosi, gestione ed eventi clinici dei pazienti con cardiopatia ischemica
  • Stratificazione del rischio
  • Outcomes research in cardiology
  • Machine learning techniques applied to cardiovascular research

Laboratori/strumentazione:

  • Sistemi di registrazione ECG, ECG Holter, Holter pressorio
  • Ecocardiogramma
  • Test da Sforzo
  • Optical Coherence Tomography
  • Software statistici per elaborazione dei dati

Collaborazioni internazionali:

  • University of Bucharest (Bucharest, Romania)
  • University of Belgrade (Belgrade, Serbia)
  • University of Skopje (Skopje, Macedonia)
  • University of Zagreb (Zagreb, Croatia)
  • Department of Electrical and Computer Engineering, University of California, Los Angeles (UCLA)

Elenco pubblicazioni anno 2017-2019:

  1. Cenko E, van der Schaar M, Yoon J, Kedev S, Valvukis M, Vasiljevic Z, Ašanin M, Miličić D, Manfrini O, Badimon L, Bugiardini R. Sex-Specific Treatment Effects After Primary Percutaneous Intervention: A Study on Coronary Blood Flow and Delay to Hospital Presentation. J Am Heart Assoc. 2019 Feb 19;8(4):e011190. doi: 10.1161/JAHA.118.011190.
  2. Vaccarino V, Badimon L, Bremner JD, Cenko E, Cubedo J, Dorobantu M, Duncker DJ, Koller A, Manfrini O, Milicic D, Padro T, Pries AR, Quyyumi AA, Tousoulis D, Trifunovic D, Vasiljevic Z, de Wit C, Bugiardini R; ESC Scientific Document Group Reviewers . Depression and coronary heart disease: 2018 ESC position paper of the working group of coronary pathophysiology and microcirculation developed under the auspices of the ESC Committee for Practice Guidelines. Eur Heart J. 2019. doi: 10.1093/eurheartj/ehy913
  3. Bugiardini R. Coronary Microcirculation and Ischemic Heart Disease, Today. Curr Pharm Des. 2018;24:2891-2892. doi: 10.2174/138161282425181108122133.
  4. Bugiardini R, Manfrini O, Cenko E. Female sex as a biological variable: A review on younger patients with acute coronary syndrome. Trends Cardiovasc Med. 2019;29:50-55. doi: 10.1016/j.tcm.2018.06.002.
  5. Manfrini O, Cenko E, Ricci B, Bugiardini R. Post Cardiovascular Surgery Atrial Fibrillation. Biomarkers Determining Prognosis. Curr Med Chem.2019;26:916-924. doi: 10.2174/0929867324666170727104930.
  6. Thygesen K, Alpert JS, Jaffe AS, Chaitman BR, Bax JJ, Morrow DA, White HD; ESC
    Scientific Document Group. Fourth universal definition of myocardial infarction (2018). Eur
    Heart J.2019;40:237-269. doi: 10.1093/eurheartj/ehy462.
  7. Cenko E, Bergami M, Varotti E, Bugiardini R. Vasospastic Angina and its Relationship with the Coronary Microcirculation. Curr Pharm Des.2018;24(25):2906-2910. doi: 10.2174/1381612824666180625150833.
  8. Manfrini O, Amaduzzi PL, Cenko E, Bugiardini R. Prognostic implications of peripheral artery disease in coronary artery disease. Curr Opin Pharmacol. 2018;39:121-128. doi: 10.1016/j.coph.2018.04.005.
  9. Cenko E, Yoon J, Kedev S, Stankovic G, Vasiljevic Z, Krljanac G, Kalpak O, Ricci B, Milicic D, Manfrini O, van der Schaar M, Badimon L, Bugiardini R. Sex Differences in Outcomes After STEMI: Effect Modification by Treatment Strategy and Age. JAMA Intern Med. 2018;178:632-639. doi: 10.1001/jamainternmed.2018.0514.
  10. Ricci B, Cenko E, Vasiljevic Z, Stankovic G, Kedev S, Kalpak O, Vavlukis M, Zdravkovic M, Hinic S, Milicic D, Manfrini O, Badimon L, Bugiardini R. Acute Coronary Syndrome: The Risk to Young Women. J Am Heart Assoc. 2017;6(12). pii: e007519. doi: 10.1161/JAHA.117.007519.
  11. Bugiardini R, Cenko E. A Short History of Vasospastic Angina. J Am Coll Cardiol. 2017;70:2359-2362. doi: 10.1016/j.jacc.2017.09.034.
  12. Valaperta R, De Siena C, Cardani R, Lombardia F, Cenko E, Rampoldi B, Fossati B, Brigonzi E, Rigolini R, Gaia P, Meola G, Costa E, Bugiardini R. Cardiac involvement in myotonic dystrophy: The role of troponins and N-terminal pro B-type natriuretic peptide. 2017;267:110-115. doi:10.1016/j.atherosclerosis.2017.10.020.
  13. Valgimigli M, Bueno H, Byrne RA, Collet JP, Costa F, Jeppsson A, Jüni P, Kastrati A, Kolh P, Mauri L, Montalescot G, Neumann FJ, Petricevic M, Roffi M, Steg PG, Windecker S, Zamorano JL, Levine GN; ESC Scientific Document Group. 2017 ESC focused update on dual antiplatelet therapy in coronary artery disease developed in collaboration with EACTS. Eur J Cardiothorac Surg. 2018;53:34-78. doi: 10.1093/ejcts/ezx334.
  14. Badimon L, Bugiardini R, Cenko E, Cubedo J, Dorobantu M, Duncker DJ, Estruch R, Milicic D, Tousoulis D, Vasiljevic Z, Vilahur G, de Wit C, Koller A. Position  paper of the European Society of Cardiology-working group of coronary pathophysiology and microcirculation: obesity and heart disease. Eur Heart J. 2017;38:1951-1958. doi: 10.1093/eurheartj/ehx181.
  15. Ibanez B, James S, Agewall S, Antunes MJ, Bucciarelli-Ducci C, Bueno H, Caforio ALP, Crea F, Goudevenos JA, Halvorsen S, Hindricks G, Kastrati A, Lenzen MJ, Prescott E, Roffi M, Valgimigli M, Varenhorst C, Vranckx P, Widimský P; ESC Scientific Document Group . 2017 ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation: The Task Force for the management of acute myocardial infarction in patients presenting with ST-segment elevation of the European Society of Cardiology (ESC). Eur Heart J. 2018;39:119-177. doi: 10.1093/eurheartj/ehx393.
  16. Bugiardini R, Ricci B, Cenko E, Vasiljevic Z, Kedev S, Davidovic G, Zdravkovic M, Miličić D, Dilic M, Manfrini O, Koller A, Badimon L. Delayed Care and Mortality Among Women and Men With Myocardial Infarction. J Am Heart Assoc. 2017;6(8). pii: e005968. doi: 10.1161/JAHA.117.005968.
  17. Valgimigli M, Bueno H, Byrne RA, Collet JP, Costa F, Jeppsson A, Jüni P, Kastrati A, Kolh P, Mauri L, Montalescot G, Neumann FJ, Petricevic M, Roffi M, Steg PG, Windecker S, Zamorano JL, Levine GN; ESC Scientific Document Group ; ESC Committee for Practice Guidelines (CPG) ; ESC National Cardiac Societies . 2017 ESC focused update on dual antiplatelet therapy in coronary artery disease developed in collaboration with EACTS: The Task Force for dual antiplatelet therapy in coronary artery disease of the European Society of Cardiology (ESC) and of the European Association for Cardio-Thoracic Surgery (EACTS). Eur Heart J. 2018;39:213-260. doi: 10.1093/eurheartj/ehx419.
  18. Cenko E, Ricci B, Kedev S, Vasiljevic Z, Dorobantu M, Gustiene O, Knežević B, Miličić D, Dilic M, Manfrini O, Koller A, Badimon L, Bugiardini R. Invasive versus conservative strategy in acute coronary syndromes: The paradox in women’s Int J Cardiol. 2016;222:1110-1115. doi:10.1016/j.ijcard.2016.07.211.
  19. Ricci B, Manfrini O, Cenko E, Vasiljevic Z, Dorobantu M, Kedev S, Davidovic G, Zdravkovic M, Gustiene O, Knežević B, Miličić D, Badimon L, Bugiardini R. Primary percutaneous coronary intervention in octogenarians. Int J Cardiol. 2016;222:1129-1135. doi: 10.1016/j.ijcard.2016.07.204.
  20. Bugiardini R. Editorial (Thematic Issue: What’s Behind the Sex Gap in Cardiovascular Mortality?). Curr Pharm Des. 2016;22:3777-8.
  21. Cenko E, Bergami M, Varotti E, Bugiardini R. Vasospastic Angina and its Relationship with the Coronary Microcirculation. Curr Pharm Des. 2018;24:2906-2910. doi: 10.2174/1381612824666180625150833.
  22. Cenko E, Ricci B, Kedev S, Kalpak O, Câlmâc L, Vasiljevic Z, Knežević B, Dilic M, Miličić D, Manfrini O, Koller A, Dorobantu M, Badimon L, Bugiardini R. The no-reflow phenomenon in the young and in the elderly. Int J Cardiol. 2016;222:1122-1128. doi: 10.1016/j.ijcard.2016.07.209.
  23. Badimon L, Bugiardini R, Cubedo J. Pathophysiology of acute coronary syndromes in the elderly. Int J Cardiol. 2016;222:1105-1109. doi: 10.1016/j.ijcard.2016.07.205
  24. Bugiardini R, Badimon L; ISACS-TC Investigators and Coordinators. The International Survey of Acute Coronary Syndromes in Transitional Countries (ISACS-TC): 2010-2015. Int J Cardiol. 2016;217 Suppl:S1-6. doi: 10.1016/j.ijcard.2016.06.219.
  25. Câlmâc L, Bătăilă V, Ricci B, Vasiljevic Z, Kedev S, Gustiene O, Trininic D, Knežević B, Miličić D, Dilic M, Manfrini O, Cenko E, Badimon L, Bugiardini R, Scafa-Udriște A, Tăutu O, Dorobanțu M. Factors associated with use of percutaneous coronary intervention among elderly patients presenting with ST segment elevation acute myocardial infarction (STEMI): Results from the ISACS-TC registry. Int J Cardiol. 2016 ;217 Suppl:S21-6. doi: 10.1016/j.ijcard.2016.06.227.
  26. Manfrini O, Ricci B, Cenko E, Dorobantu M, Kalpak O, Kedev S, Kneževic B, Koller A, Milicic D, Vasiljevic Z, Badimon L, Bugiardini R; ISACS-TC Investigators. Association between comorbidities and absence of chest pain in acute coronary syndrome with in-hospital outcome. Int J Cardiol. 2016;217 Suppl:S37-43. doi: 10.1016/j.ijcard.2016.06.221.
  27. Cenko E, Hall M, Bugiardini R. Big data: a new look at old problems. Eur Heart J Qual Care Clin Outcomes. 2016;2:144-146. doi: 10.1093/ehjqcco/qcw028.
  28. Manfrini O, Ricci B, Dormi A, Puddu PE, Cenko E, Bugiardini R. Early Invasive Strategy for Unstable Angina: a New Meta-Analysis of Old Clinical Trials. Sci Rep. 2016;6:27345. doi: 10.1038/srep27345.
  29. Bugiardini R, Cenko E. Persisting chest pain in nonobstructive coronary artery disease. Eur Heart J Qual Care Clin Outcomes. 2016;2(2):69-71. doi10.1093/ehjqcco/qcw010
  30. Cenko E, Bugiardini R. Barriers to Risk Stratification Accuracy in Ischemic Heart Disease in Women: The Role of Non-Obstructive Coronary Artery Disease. Curr Pharm Des. 2016;22:3928-34.
  31. Bugiardini R, Cenko E, Ricci B, Vasiljevic Z, Dorobantu M, Kedev S, Vavlukis M, Kalpak O, Puddu PE, Gustiene O, Trninic D, Knežević B, Miličić D, Gale CP, Manfrini O, Koller A, Badimon L. Comparison of Early Versus Delayed Oral β Blockers in Acute Coronary Syndromes and Effect on Outcomes. Am J Cardiol. 2016;117:760-7. doi: 10.1016/j.amjcard.2015.11.059.
  32. Cenko E, Ricci B, Kedev S, Vasiljevic Z, Dorobantu M, Gustiene O, Kneževic B, Milicic D, Dilic M, Trninic D, Smith F, Manfrini O, Badimon L, Bugiardini R. Reperfusion therapy for ST-elevation acute myocardial infarction in Eastern Europe: the ISACS-TC registry. Eur Heart J Qual Care Clin Outcomes. 2016;2:45-51. doi: 10.1093/ehjqcco/qcv025.
  33. Roffi M, Patrono C, Collet JP, Mueller C, Valgimigli M, Andreotti F, Bax JJ, Borger MA, Brotons C, Chew DP, Gencer B, Hasenfuss G, Kjeldsen K, Lancellotti P,  Landmesser U, Mehilli J, Mukherjee D, Storey RF, Windecker S; ESC ScientificDocument Group . 2015 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation: Task Force for the Management of Acute Coronary Syndromes in Patients Presenting without Persistent ST-Segment Elevation of the European Society of Cardiology (ESC). Eur Heart J. 2016;37:267-315. doi: 10.1093/eurheartj/ehv320.
  34. Vasiljevic-Pokrajcic Z, Mickovski N, Davidovic G, Asanin M, Stefanovic B, Krljanac G, Radosavljevic-Radovanovic M, Radovanovic N, Lasica R, Milanović S, Bjekić J, Majstorovic-Stakic M, Trifunovic D, Karadzic A, Rajic D, Milosevic A, Zdravkovic M, Saric J, Bugiardini R. Sex and age differences and outcomes in acute coronary syndromes. Int J Cardiol. 2016;217 Suppl:S27-31. doi: 1016/j.ijcard.2016.06.217.