Telecardiologia & Applicazioni Cliniche di Modelli Numerici di Sistemi Biologici (Claudio De Lazzari)

Unità di Ricerca: Telecardiologia & Applicazioni Cliniche di Modelli Numerici di Sistemi Biologici

Coordinatore: Claudio De Lazzari

Sede CNR: Dipartimento di Scienze Biomediche, Istituto di Fisiologia Clinica, Sezione di Roma.

Indirizzo : Via Palestro, 32

tel: (+39) 06 4993 6222
fax: (+39) 06 4993 2688
e-mail: claudio.delazzari@ifc.cnr.it
sito web: https://www.ifc.cnr.it/index.php/it/spotlight/387-prestigioso-riconoscimento-all-ing-claudio-de-lazzari
http://www.cnr.it/peoplepublic/peoplepublic/index/schedaeng/u/claudio.delazzari
http://cardiosim.dsb.cnr.it/

Linee di ricerca:
RESPIRATORY SYSTEM MODELING: of heart-lung interaction during mechanical ventilation and mechanical circulatory assistance. Thoracic artificial Lung (TAL) and Extracorporeal Membrane Oxygenation (ECMO): R&D on 0-D numerical and hybrid (numerical/hydraulic) models. Clinical data validation.
CARDIAC RESYNCHRONIZATION THERAPY (CRT): R&D on a numerical model of the cardiovascular system enables to reproduce severe and moderate heart failure (HF) and the effects of cardiac resynchronization therapy (CRT) using a biventricular pacemaker. The software will be useful for cardiologist to optimize pacemaker temporization.
VENTRICULAR ASSIST DEVICES PROTOCOLS: R&D on Ventricular Assist Devices (VADs) protocols for the management of pulsatile and continuous flow VADs: “in vitro” test for pulsatile/continuous flow pumps.
IABP & ECMO: R&D on a new numerical models of the intra-aortic balloon pump and ECMO devices. Clinical data validation.
R&D ON ONTOLOGIES IN THE FIELD OF CARDIOVASCULAR ENGINEERING: Applications on mechanical assist devices, heart valves and biomedical equipments. R&D on ontologies applied to pharmacovigilance to analyze adverse experiences related to drug assumption.
TELECARDIOLOGY: Telecardiology pilot study designed for students in order to prevent cases of sudden cardiac death (SCD). R&D on wearable device enables to acquire and send in-real time several haemodynamic parameters and electrical signals. The device is equipped with a software enabling to predict (using numerical models) starting from measured data, haemodynamic and energetic parameter values that cannot be directly measured.
NUMERICAL STEM CELL THERAPY: R&D on a numerical model to analyze nutrient transport and cardiac stem cell proliferation in an ischemic area of the heart. Simulation of stem cell therapy for different types of HF. In silico and in vitro study.

E-LEARNING AND MEDICAL SIMULATION TRAINING (MST): courses for medical clinical and biomedical engineer students and for physicians and other medical professionals (i.e. Cardilogists, Cardiac Surgeons, Anesthesiologists, Family medicine physicians, Clinical perfusionists nurses, etc.).
MST courses at Geomedi University-Medical Faculty (Georgia) in cooperation with Department of Cardiovascular, Respiratory, Anaesthetic and Geriatric Sciences, Sapienza University, (Rome – Italy) and with Uniklinik RWTH (Aachen Clinics) Institute of Physiology (Aachen University – Germany).
MST courses at Department of Cardiovascular, Respiratory, Anaesthetic and Geriatric Sciences, Sapienza University, (Rome – Italy). Higher Education Course called “Il Paziente “virtuale” per la Formazione in Cardiologia”.
MST courses at RWTH Aachen University in the context of “Master’s of Science program in Biomedical Engineering”.

Laboratori/strumentazione:
LABORATORI STRUMENTAZIONE
Informatica 4 Stazioni di lavoro complete di Computer, Stampanti, Scanner. WiFi per collegare devices.
Elettronica Oscilloscopio analogico; Oscilloscopio digitale; Tester; Amplificatori di potenza; Alimentatori; Generatore di funzione; Serie completa di resistenze, condensatori, transistor, led, circuiti integrati; Capacimetro;
Serie completa di manuali di Elettronica/Elettrotecnica; Termometro digitale; Cavetteria; Saldatori termostatati; Succhiastagno; Motori passo-passo; Banco lavoro; Pinze becco piatto; Pinze punta curva; Trapano da circuito stampato; Spelafili.
Meccanica Compressore; Piegatrice; Banco lavoro; Taglierina; Trapano a colonna; Chiavi inglesi; Brucole; Set cacciaviti a taglio e croce; Martelli; Pinze; Tenaglie; Punte da trapano per ferro.

Collaborazioni internazionali: Laboratory for Extracorporeal Circulation Research (ECCLab) – Aachen University (DE); Department of Biomedical Engineering (University of Strathclyde-UK); Medical Faculty of Geomedi University (Georgia); Medical Faculty of Tehran University; Univ.-Klinik für Radiologie, Innsbruck Medical University (Austria); University of Applied Sciences Wiener Neustadt (Austria); Medizinische Universitaet Innsbruck (Austria); Cardiocentro Ticino, Lugano (Switzerland); Faculty of Software and Information Science, Iwate Prefectural University, (Japan); Université du Québec à Montréal (Canada); Golden Jubilee National Hospital, Clydebank-Glasgow (UK); Cardiac Surgery Unit, University Hospitals of Leicester NHS Trust, Leicester (UK).

LIST OF PUBLICATIONS

 

  1. 2020 De Lazzari, B. De Lazzari, A. Iacovoni, S. Marconi, S. Papa, M. Capoccia, R. Badagliacca, C.D. Vizza. Intra-Aortic Balloon Counterpulsation Timing: A New Numerical Model for Programming and Training in the Clinical Environment. Computer Methods and Programs in Biomedicine, 194, (https://doi.org/10.1016/j.cmpb.2020.105537).
  1. 2020 Marconi and C. De Lazzari. In silico study of airway/lung mechanics in normal human breathing. Mathematics and Computers in Simulation, (https://doi.org/10.1016/j.matcom.2020.05.014).
  1. 2019 De Lazzari, S. Marconi, M. Capoccia, S. Papa, R. Badagliacca, C.D. Vizza. A 0-D Model to Predict the Relationship between Resistance and Compliance in Pulmonary Arterial Hypertension. Proceedings of the 31TH European Modeling and Simulation Symposium. (ISBN 978-88-85741-25-6). Edit by Affenzeller, Bruzzone, Longo, Piera 23-28
  1. 2019 De Lazzari, M. Capoccia, S. Marconi. How can LVAD support influence ventricular energetics parameters in advanced heart failure patients? A retrospective study .Computer Methods and Programs in Biomedicine, 172, 117-126. (https://doi.org/10.1016%2Fj.cmpb.2019.02.012)
  1. 2018 Marconi, C. De Lazzari. A Lumped Parameter Model of Airway/Lung Mechanics. Proceedings of the 30TH European Modeling and Simulation Symposium. (ISBN 978-88-85741-03-4). Edit by Affenzeller, Bruzzone, Jiménez, Longo, Merkuryev and Piera. 54-58.
  1. 2018 Marconi, M. Ledda, A.M. Bersani, I. Giorgio, A. Lisi, E. Bersani, D. Andreucci, I. Genuini, D.M. Pisanelli, C. De Lazzari. Multidisciplinary Approach to Myocardial Regeneration: In Vitro and In Silico Studies of Stem Cells Behaviour. New trends in software methodologies, tools and techniques. Proceedings of SoMeT 2018. (ISBN 978-1-61499-899-0). Edit by H. Fujita, E. Herrera-Viedma IOS Press (Amsterdam), vol. 303; 121 – 134. doi: 10.3233/978-1-61499-900-3-121
  1. 2018M. Pisanelli, C. De Lazzari, I. Genuini. An Ontology of Mechanical Circulatory Assist Devices Aimed at the Realization of a Decision Support System. New trends in software methodologies, tools and techniques. Proceedings of SoMeT 2018. (ISBN 978-1-61499-899-0). Edit by H. Fujita, E. Herrera-Viedma IOS Press (Amsterdam), vol. 303; 507 – 514. doi: 10.3233/978-1-61499-900-3-507
  1. 2018 Capoccia, S. Marconi, and C. De Lazzari. Decision-making in advanced heart failure patients requiring LVAD insertion: Can preoperative simulation become the way forward? A case study. Journal of Biomedical Engineering and Informatics, 4(2); 8-20. doi: https://doi.org/10.5430/jbei.v4n2p8
  1. 2018 Capoccia, S. Marconi, C. De Lazzari. A Simulation Approach to Guide Therapeutic Intervention in Advanced Heart Failure. PROCEEDINGS of BioMedEng18 Conference (ISBN 978-1-9996465-0-9),87. https://www.biomedeng18.com/conference-proceedings
  1. 2018 Ledda, E. D’Emilia, M.G. Lolli, R. Marchese, C. De Lazzari and A. Lisi. Non-Ionizing Radiation for Cardiac Human Amniotic Mesenchymal Stromal Cell Commitment: A Physical Strategy in Regenerative Medicine. Int. J. Mol. Sci. 19(8), 2324. doi: https://doi.org/10.3390/ijms19082324

BOOKS and CHAPTERS

  • 2019 De Lazzari, M. Capoccia. CONCEPTS, MATHEMATICAL MODELLING AND APPLICATIONS IN HEART FAILURE. M. Capoccia and C. De Lazzari Eds.  New York:  Nova Science Publisher. (ISBN: 978-1-53614-771-1).
  • 2019 Capoccia and C. De Lazzari. Mechanical Circulatory Assist Devices: Overview. In: CONCEPTS, MATHEMATICAL MODELLING and APPLICATIONS in HEART FAILURE.  Massimo Capoccia and Claudio De Lazzari Eds.  New York:  Nova Science Publisher. (ISBN: 978-1-53614-771-1), 1-22.
  • 2019 Capoccia, S. Marconi and C. De Lazzari. Review of Pressure-Volume Analysis. In: CONCEPTS, MATHEMATICAL MODELLING and APPLICATIONS in HEART FAILURE.  Massimo Capoccia and Claudio De Lazzari Eds.  New York:  Nova Science Publisher. (ISBN: 978-1-53614-771-1), 23-76.
  • 2019 De Lazzari, S. Marconi and M. Capoccia. Physiology of Ventricular Interdependence. In: CONCEPTS, MATHEMATICAL MODELLING and APPLICATIONS in HEART FAILURE.  Massimo Capoccia and Claudio De Lazzari Eds.  New York:  Nova Science Publisher. (ISBN: 978-1-53614-771-1), 77-118.
  • 2019 Marconi, M. Capoccia and C. De Lazzari. Mathematical Modelling of the Cardiovascular System

In: CONCEPTS, MATHEMATICAL MODELLING and APPLICATIONS in HEART FAILURE.  Massimo Capoccia and Claudio De Lazzari Eds.  New York:  Nova Science Publisher. (ISBN: 978-1-53614-771-1), 119-158.

  • 2019 De Lazzari, S. Marconi and M. Capoccia. Interactions Between VADs and the Cardiovascular System. In: CONCEPTS, MATHEMATICAL MODELLING and APPLICATIONS in HEART FAILURE.  Massimo Capoccia and Claudio De Lazzari Eds.  New York:  Nova Science Publisher. (ISBN: 978-1-53614-771-1), 159-196.
  • 2019 Capoccia, S. Marconi and C. De Lazzari. Mathematical Modelling of Mechanical Circulatory Support. In: CONCEPTS, MATHEMATICAL MODELLING and APPLICATIONS in HEART FAILURE.  Massimo Capoccia and Claudio De Lazzari Eds. New York:  Nova Science Publisher. (ISBN: 978-1-53614-771-1), 261-298.
  • 2019 De Lazzari, S. Saltarocchi, I. Genuini and M. Capoccia. Clinical Applications. In: CONCEPTS, MATHEMATICAL MODELLING and APPLICATIONS in HEART FAILURE.  Massimo Capoccia and Claudio De Lazzari Eds.  New York:  Nova Science Publisher. (ISBN: 978-1-53614-771-1), 337-366.

Elenco pubblicazioni del triennio 2016 – 2018:

2018 M. Capoccia, S. Marconi, S. A. Singh, D.M. Pisanelli and C. De Lazzari. Simulation as a Preoperative Planning Approach in Advanced Heart Failure Patients. A Retrospective Clinical Analysis. In Press on BioMedical Engineering OnLine.

2018 S. Marconi, C. Cappelli, M. Capoccia, D.M. Pisanelli, I. Genuini, C. De Lazzari. A New Numerical Model of the Intra-Aortic Balloon Pump as a Tool for Clinical Simulation and Outcome Prediction. IFMBE Proceeding of World Congress on Medical Physics and Biomedical Engineering. June 3-8, 2018, Prague (Czech Republic),

2017 M. Capoccia, S.A. Singh, C. De Lazzari. The Role of Simulation for Preoperative Planning in Patients Requiring Mechanical Circulatory Support. In: Eskola H., Väisänen O., Viik J., Hyttinen J. (eds) EMBEC & NBC 2017. EMBEC 2017, NBC 2017 (ISBN 978-981-10-5122-7). Tampere 11-15 June 2017, IFMBE Proceeding, vol. 65, 559-562. doi: 10.1007/978-981-10-5122-7_140.

2017 C. De Lazzari, M. Pirckhalava Eds (2017). Book: CARDIOVASCULAR and PULMONARY ARTIFICIAL ORGANS: EDUCATIONAL TRAINING SIMULATORS. Published by Consiglio Nazionale delle Ricerche (CNR) ROMA (ISBN 978-88-8080-240-2).

2017 R. Badagliacca, S. Papa, G. Valli, B. Pezzuto, R. Poscia, M. Reali, G. Manzi, E. Giannetta, D. Berardi, S. Sciomer, P. Palange, F. Fedele, R. Naeije, C.D. Vizza. Right ventricular dyssynchrony and exercise capacity in idiopathic pulmonary arterial hypertension. Eur. Respir. J., 49(6). pii: 1601419. doi: 10.1183/13993003.01419-2016.

2017 C. De Lazzari, M. Pirckhalava. “Medical Simulators for E-Learning and Teaching in Healthcare”, in CARDIOVASCULAR and PULMONARY ARTIFICIAL ORGANS: EDUCATIONAL TRAINING SIMULATORS. C. De Lazzari, M. Pirckhalava Eds. Published by Consiglio Nazionale delle Ricerche (CNR) ROMA (ISBN 978-88-8080-240-2), 1-15.

2017 F. Fedele, M. Mancone, F. Adamo, P. Severino. Heart Failure With Preserved, Mid-Range, and Reduced Ejection Fraction: The Misleading Definition of the New Guidelines. Cardiol. Rev., 25(1), 4-5.

2017 B. De Lazzari, B. Quatember, K. Mottaghy, C. De Lazzari. “Numerical Models of the Cardiovascular System: Interaction Between the Septum and the Left (Right) Ventricular and Atrial Free Wall”, in CARDIOVASCULAR and PULMONARY ARTIFICIAL ORGANS: EDUCATIONAL TRAINING SIMULATORS. C. De Lazzari, M. Pirckhalava Eds. Published by Consiglio Nazionale delle Ricerche (CNR) ROMA (ISBN 978-88-8080-240-2), 17-31.

2017 S. Gili, M. Mancone, F. Ballocca, W. Grosso Marra, A Calcagno, G. D’Ettorre, M. Cannillo, F. D’Ascenzo, G. Orofino, L. Marruncheddu, E. Lonni, A. Cinque, F. Vullo, G. Ceccarelli, I. Vilardi, G. Sardella, V. Vullo, C. Moretti, F. Fedele, S. Bonora, F. Gaita. Prevalence and predictors of long corrected QT interval in HIV-positive patients: a multicenter study. J. Cardiovasc. Med. (Hagerstown), 18(7), 539-544. doi: 10.2459/JCM.0000000000000436.

2017 C. De Lazzari, M. Capoccia. “In Silico Modelling of Right Continuous Flow Circulatory Support to Simulate RVAD Assistance”, in CARDIOVASCULAR and PULMONARY ARTIFICIAL ORGANS: EDUCATIONAL TRAINING SIMULATORS. C. De Lazzari, M. Pirckhalava Eds. Published by Consiglio Nazionale delle Ricerche (CNR) ROMA (ISBN 978-88-8080-240-2), 65-86.

2017 F. Fedele, K. Karason, S. Matskeplishvili. Pharmacological approaches to cardio-renal syndrome: a role for the inodilator levosimendan. Eur Heart J Suppl. 19(Suppl C), C22-C28.

2017 A.M. Bersani, E. Bersani, C. De Lazzari. “Interaction Between the Respiratory and Cardiovascular System: a Simplified 0-D Mathematical Model”, in CARDIOVASCULAR and PULMONARY ARTIFICIAL ORGANS: EDUCATIONAL TRAINING SIMULATORS. C. De Lazzari, M. Pirckhalava Eds. Published by Consiglio Nazionale delle Ricerche (CNR) ROMA (ISBN 978-88-8080-240-2), 87-103.

2017 R. Badagliacca, R. Poscia, B. Pezzuto, S. Papa, M. Reali, F. Pesce, G. Manzi, D. Gianfrilli, F. Ciciarello, S. Sciomer, G. Biondi-Zoccai, R. Torre, F. Fedele, C.D. Vizza. Prognostic relevance of right heart reverse remodeling in idiopathic pulmonary arterial hypertension. J. Heart Lung Transplant. Oct 2. pii: S1053-2498(17)32041-7. doi: 10.1016/j.healun.2017.09.026.

2017 C. De Lazzari, B. De Lazzari, I. Genuini M. Pirckhalava. “The Use of e-Learning for Healthcare Professionals: an Interactive in Silico Simulator”, in CARDIOVASCULAR and PULMONARY ARTIFICIAL ORGANS: EDUCATIONAL TRAINING SIMULATORS. C. De Lazzari, M. Pirckhalava Eds. Published by Consiglio Nazionale delle Ricerche (CNR) ROMA (ISBN 978-88-8080-240-2), 161-181.

2017 M. Cicenia, F. Fedele, V. Petronilli, C. De Carlo, F. Moscucci, M. Schina, S. Sciomer. Hidden in the heart: A peculiar type of left ventricular remodeling after acute myocardial infarction. Echocardiography, 34(11), 1738-1739. doi: 10.1111/echo.13658

2017 A. Cinque, F. Fedele, B. Quatember, I Genuini C. De Lazzari. “Interaction Between Mechanical Ventilation and Biventricular Pacemaker: Haemodynamic Studies Using Medical Simulation Software Platform”, in CARDIOVASCULAR and PULMONARY ARTIFICIAL ORGANS: EDUCATIONAL TRAINING SIMULATORS. C. De Lazzari, M. Pirckhalava Eds. Published by Consiglio Nazionale delle Ricerche (CNR) ROMA (ISBN 978-88-8080-240-2), 183-201.

2016 C. De Lazzari, B. Quatember. CARDIOSIM©: A Numerical Simulator and its Application to Study the Interactions between Mechanical Circulatory Assist Devices and the Native Cardiovascular System. eBook: Ventricular Assist Devices (ISBN 978-1-944685-59-1). Published by SM Group Dover, DE 19904 (USA). http://www.smgebooks.com/ventricular-assist-devices/index.php

2016 R. Badagliacca, R. Poscia, B. Pezzuto, S. Papa, F. Pesce, G. Manzi, E. Giannetta, C. Raineri, M. Schina, S. Sciomer, D. Parola, M. Francone, I. Carbone, F. Fedele, C.D. Vizza. Right ventricular concentric hypertrophy and clinical worsening in idiopathic pulmonary arterial hypertension. J. Heart Lung Transplant., 35(11), 1321-1329. doi: 10.1016/j.healun.2016.04.006.

2016 C. De Lazzari, B. Quatember. Cardiac Energetics in Presence of Lung Assist Devices: In Silico Study. Modeling and Numerical Simulation of Material Science, 6(3), 41-57 (ISSN Print 2164-5345 —— ISSN Online 2164-5353). doi: http://dx.doi.org/10.4236/mnsms.2016.63005

2016 A. Ceccacci, M. Mancone, S. Calcagno, G. De Vincentis, G. Sardella, F. Fedele. Role of MIBG scintigraphy in reverse Tako-tsubo cardiomyopathy: Confirming a pathophysiologic hypothesis. Int. J. Cardiol., 15, 223, 54-55. doi: 10.1016/j.ijcard.2016.08.190.

2016 C. De Lazzari, I. Genuini, M.C. Gatto, A. Cinque, M. Mancone, A. D’Ambrosi, E. Silvetti, A. Fusto, D.M. Pisanelli, F. Fedele. Screening high school students in Italy for sudden cardiac death prevention by using a telecardiology device: a retrospective observational study. Cardiology in the Young, Mar (4), 1-8.
doi: http://dx.doi.org/10.1017/S1047951116000147

2016 A.M. Bersani, D. Andreucci, E. Bersani, I. Giorgio, M. Ledda, A. Lisi and C. De Lazzari. A mathematical model of the action of stem cells for cardiac tissue. PROCEEDINGS OF SIMAI 2016 THE XIII BIANNUAL CONGESS OF SIMAI. Milan 13-16 September 2016, 167-168.

2016 G. Sardella, L. Lucisano, R. Garbo, M. Pennacchi, E. Cavallo, R.E. Stio, S. Calcagno, F. Ugo, G. Boccuzzi, F. Fedele, M. Mancone. Single-Staged Compared With Multi-Staged PCI in Multivessel NSTEMI Patients: The SMILE Trial. J. Am. Coll. Cardiol., 26, 67(3), 264-72.