Unità di Ricerca: Farmacologia Cardiovascolare e Farmacovigilanza

Unità di Ricerca: Farmacologia Cardiovascolare e Farmacovigilanza

Coordinatore: Prof. Alessandro Mugelli

Sede Universitaria:

Università di Firenze, Dipartimento di Neuroscienze, Psicologia, Area del Farmaco e Salute del Bambino (NEUROFARBA)

Viale Pieraccini 6, 50139, Firenze

Tel: + 39 055 2758209

e-mail: alessandro.mugelli@unifi.it

https://www.neurofarba.unifi.it/vp-91-sezione-di-farmacologia-e-tossicologia.html

https://www.neurofarba.unifi.it/vp-153-unita-di-ricerca-in-farmacovigilanza-e-farmacoepidemiologia.html

Linee di ricerca:

  • Modulazione farmacologica dell’accoppiamento eccitazione-contrazione in preparati cardiaci.
  • Rimodellamento funzionale nella cardiomiogenesi e nelle patologie cardiache (ipertrofia, insufficienza, diabete, fibrillazione atriale)
  • Farmacovigilanza e Farmacoepidemiologia

Laboratori/strumentazione:

  • Sistemi di registrazione elettrofisiologica in patch-clamp e multicellulari;
  • Microscopia a epifluorescenza;
  • Sistema di perfusione alla Langendorf;
  • Incubatori per colture cellulari;
  • Cappe chimiche/biologiche;
  • Strumentazione completa per analisi proteiche e genetiche (western-blot, immunofluorescenza, RT-PCR qualitativa e quantitativa)
  • Transilluminatore
  • Strumentazione di base chimica e biologica (centrifughe, bagnetti termostatati, termociclatori, ecc.).

Collaborazioni internazionali:

  • Biel M, Universität München, München, Germany
  • Eisner D, University of Manchester, Manchester, United Kingdom
  • Fischmeister R, University of Paris-Sud, Paris-Sud, France
  • Jaconi ME, University of Geneva, Geneva, Switzerland
  • Kohl P, University of Oxford, United Kingdom
  • Koidl B, University of Graz, Graz, Austria
  • Nattel S, Montreal Heart Institute and Univrsity of Montreal, Montreal, Canada
  • Ravens U, University of Dresden, Dresden, Germany
  • Schotten U, University of Maastricht, Maastricht, The Neaderland
  • Varro A, University of Szeged, Szeged, Hungary

Elenco pubblicazioni anno 2019:
1. Kirchmayer U, Sorge C, Sultana J, Lapi F, Onder G, Agabiti N, Cascini S, Roberto G,
Corrao G, Vitale C, Lucenteforte E, Mugelli A, Davoli M. Bisphosphonates and
cardiovascular risk in elderly patients with previous cardiovascular disease: a populationbased nested case-control study in Italy. Ther Adv Drug Saf. 2019;10:2042098619838138.
doi: 10.1177/2042098619838138. eCollection 2019.

2. Lombardi N, Crescioli G, Bettiol A, Menniti-Ippolito F, Maggini V, Gallo E, Mugelli A,
Vannacci A, Firenzuoli F. Safety of complementary and alternative medicine in children: A
16-years retrospective analysis of the Italian Phytovigilance system database.
Phytomedicine. 2019;61:152856. doi:10.1016/j.phymed.2019.152856. [

3. Johnson DM, Mugelli A, Cerbai E. Editorial: The Role of Calcium Handling in Heart
Failure and Heart Failure Associated Arrhythmias. Front Physiol. 2019;10:1.
doi:10.3389/fphys.2019.00001.

4. Bettiol A, Lombardi N, Crescioli G, Maggini V, Gallo E, Mugelli A, Firenzuoli F, Baronti
R, Vannacci A. Galenic Preparations of Therapeutic Cannabis sativa Differ in Cannabinoids
Concentration: A Quantitative Analysis of Variability and Possible Clinical Implications.
Front Pharmacol. 2019;9:1543. doi:10.3389/fphar.2018.01543.

5. Lucenteforte E, Vannacci A, Crescioli G, Lombardi N, Vagnoli L, Giunti L, Cetica V,
Coniglio ML, Pugi A, Bonaiuti R, Aricò M, Giglio S, Messeri A, Barale R, Giovannelli L,
Mugelli A, Maggini V. Opioid response in paediatric cancer patients and the Val158Met
polymorphism of the human catechol-O-methyltransferase (COMT) gene: an Italian study
on 87 cancer children and a systematic review. BMC Cancer. 2019;19(1):113. doi:
10.1186/s12885-019-5310-4.

6. Sultana J, Giorgianni F, Rea F, Lucenteforte E, Lombardi N, Mugelli A, Vannacci A,
Liperoti R, Kirchmayer U, Vitale C, Chinellato A, Roberto G, Corrao G, Trifirò G. Allcause mortality and antipsychotic use among elderly persons with high baseline
cardiovascular and cerebrovascular risk: a multi-center retrospective cohort study in Italy.
Expert Opin Drug Metab Toxicol. 2019;15(2):179-188.
doi:10.1080/17425255.2019.1561860.

7. Zacchigna S, Sartiani L, Penna C, Varricchi G, Tocchetti CG. Modulation of Redox
Signaling in Chronic Diseases and Regenerative Medicine. Oxid Med Cell Longev.
2019;2019:6091587. doi: 10.1155/2019/6091587.

8. Romanelli MN, Del Lungo M, Guandalini L, Zobeiri M, Gyökeres A, Árpádffy-Lovas T,
Koncz I, Sartiani L, Bartolucci G, Dei S, Manetti D, Teodori E, Budde T, Cerbai E. EC18 as
a Tool To Understand the Role of HCN4 Channels in Mediating HyperpolarizationActivated Current in Tissues. ACS Med Chem Lett. 2019;10(4):584-589. doi:
10.1021/acsmedchemlett.8b00587.

9. Crocini C, Ferrantini C, Coppini R, Pavone FS, Poggesi C, Cerbai E, Sacconi L. Letter to
the Editor. J Physiol. 2019;597(11):2965-2966. doi:10.1113/JP278018.

10. Ferrantini C, Pioner JM, Martella D, Coppini R, Piroddi N, Paoli P, Calamai M, Pavone
FS, Wiersma DS, Tesi C, Cerbai E, Poggesi C, Sacconi L, Parmeggiani C. Development of
Light-Responsive Liquid Crystalline Elastomers to Assist Cardiac Contraction. Circ Res.
2019;124(8):e44-e54. doi: 10.1161/CIRCRESAHA.118.313889.

11. Foà A, Agostini V, Rapezzi C, Olivotto I, Corti B, Potena L, Biagini E, Martin Suarez S,
Rotellini M, Cecchi F, Stefano P, Coppini R, Ferrantini C, Bacchi Reggiani ML, Leone O.
Histopathological comparison of intramural coronary artery remodeling and myocardial
fibrosis in obstructive versus end-stage hypertrophic cardiomyopathy. Int J Cardiol.
2019;291:77-82. doi:10.1016/j.ijcard.2019.03.060.

12. Crocini C, Ferrantini C, Coppini R, Pavone FS, Poggesi C, Cerbai E, Sacconi L. Letter to
the Editor. J Physiol. 2019;597(11):2965-2966. doi: 10.1113/JP278018.

13. Woulfe KC, Ferrara C, Pioner JM, Mahaffey JH, Coppini R, Scellini B, Ferrantini C,
Piroddi N, Tesi C, Poggesi C, Jeong M. A Novel Method of Isolating Myofibrils From
Primary Cardiomyocyte Culture Suitable for Myofibril Mechanical Study. Front Cardiovasc
Med. 2019;6:12. doi: 10.3389/fcvm.2019.00012.

14. Ferrantini C, Coppini R, Sacconi L. Cardiomyocyte-specific Gq signalling and
arrhythmias: novel insights from DREADD technology. Cardiovasc Res. 2019;115(6):992-
994. doi: 10.1093/cvr/cvz052.

15. Mazzarotto F, Girolami F, Boschi B, Barlocco F, Tomberli A, Baldini K, Coppini R,
Tanini I, Bardi S, Contini E, Cecchi F, Pelo E, Cook SA, Cerbai E, Poggesi C, Torricelli F,
Walsh R, Olivotto I. Defining the diagnostic effectiveness of genes for inclusion in panels:
the experience of two decades of genetic testing for hypertrophic cardiomyopathy at a single
center. Genet Med. 2019;21(2):284-292. doi: 10.1038/s41436-018-0046-0.

Elenco pubblicazioni anno 2018:
16. Bettiol A, Lombardi N, Marconi E, Crescioli G, Bonaiuti R, Maggini V, Gallo E, Mugelli
A, Firenzuoli F, Ravaldi C, Vannacci A. The Impact of Previous Pregnancy Loss on
Lactating Behaviors and Use of Herbal Medicines during Breastfeeding: A Post Hoc
Analysis of the Herbal Supplements in Breastfeeding InvesTigation (HaBIT). Evid Based
Complement Alternat Med. 2018;2018:1035875. doi:10.1155/2018/1035875. .

17. Scavone C, Carnovale C, Ruggiero R, Radice S, Scatigna M, Racagni G, Mugelli A, Rossi
F, Clementi E, Capuano A. On the Policy of the Italian Government in the Discovery,
Development, and Access to Medicines. Clin Ther. 2018;40(11):1931-1940.
doi:10.1016/j.clinthera.2018.09.015.

18. Coppini R, Ferrantini C, Mugelli A, Poggesi C, Cerbai E. Altered Ca(2+) and Na(+)
Homeostasis in Human Hypertrophic Cardiomyopathy: Implications for Arrhythmogenesis.
Front Physiol. 2018;9:1391. doi:10.3389/fphys.2018.01391.

19. Rea F, Calusi G, Franchi M, Vetrano DL, Roberto G, Bonassi S, Kirchmayer U,
Chinellato A, Bettiol A, Sultana J, Mugelli A, Corrao G; I-GrADE Investigators. Adherence
of Elderly Patients with Cardiovascular Disease to Statins and the Risk of Exacerbation of
Chronic Obstructive Pulmonary Disease: Evidence from an Italian Real-World
Investigation. Drugs Aging. 2018;35(12):1099-1108. doi:10.1007/s40266-018-0600-0.

20. Scavone C, Sessa M, Clementi E, Corrao G, Leone R, Mugelli A, Rossi F, Spina E,
Capuano A. Real World Data on the Utilization Pattern and Safety Profile of Infliximab
Originator Versus Biosimilars in Italy: A Multiregional Study. BioDrugs. 2018;32(6):607-
617. doi: 10.1007/s40259-018-0313-2.

21. Trifirò G, Gini R, Barone-Adesi F, Beghi E, Cantarutti A, Capuano A, Carnovale C,
Clavenna A, Dellagiovanna M, Ferrajolo C, Franchi M, Ingrasciotta Y, Kirchmayer U, Lapi
F, Leone R, Leoni O, Lucenteforte E, Moretti U, Mugelli A, Naldi L, Poluzzi E, Rafaniello
C, Rea F, Sultana J, Tettamanti M, Traversa G, Vannacci A, Mantovani L, Corrao G. The
Role of European Healthcare Databases for Post-Marketing Drug Effectiveness, Safety and
Value Evaluation: Where Does Italy Stand? Drug Saf. 2019;42(3):347-363. doi:
10.1007/s40264-018-0732-5.

22. Volpe M, Battistoni A, Gallo G, Rubattu S, Tocci G; Writing Committee; Scientific
Societies. Executive Summary of the 2018 Joint Consensus Document on Cardiovascular
Disease Prevention in Italy. High Blood Press Cardiovasc Prev. 2018;25(3):327-341. doi:
10.1007/s40292-018-0278-8.

23. Bua S, Berrino E, Del Prete S, Murthy VS, Vijayakumar V, Tamboli Y, Capasso C,
Cerbai E, Mugelli A, Carta F, Supuran CT. Synthesis of novel benzenesulfamide derivatives
with inhibitory activity against human cytosolic carbonic anhydrase I and II and Vibrio
cholerae α- and β-class enzymes. J Enzyme Inhib Med Chem. 2018;33(1):1125-1136. doi:
10.1080/14756366.2018.1467901.

24. Spinelli V, Sartiani L, Mugelli A, Romanelli MN, Cerbai E. Hyperpolarization-activated
cyclic-nucleotide-gated channels: pathophysiological, developmental, and pharmacological
insights into their function in cellular excitability. Can J Physiol Pharmacol.
2018;96(10):977-984. doi: 10.1139/cjpp-2018-0115.

25. Pazan F, Weiss C, Wehling M; FORTA. Correction to: The EURO-FORTA (Fit fOR The
Aged) List: International Consensus Validation of a Clinical Tool for Improved Drug
Treatment in Older People. Drugs Aging. 2018;35(7):677. doi:10.1007/s40266-018-0565-z.

26. Cerbai E, Mugelli A. Lercanidipine and T-type calcium current. Eur Rev Med Pharmacol
Sci. 2018;22(12):4025-4031. doi: 10.26355/eurrev_201806_15289.

27. Di Mario C, Mugelli A, Perrone Filardi P, Rosano G, Rossi F. Long-term dual antiplatelet
therapy: pharmacological and clinical implications. J Cardiovasc Med (Hagerstown).
2018;19(8):399-410. doi: 10.2459/JCM.0000000000000677.

28. Lucenteforte E, Vagnoli L, Pugi A, Crescioli G, Lombardi N, Bonaiuti R, Aricò M, Giglio
S, Messeri A, Mugelli A, Vannacci A, Maggini V. A systematic review of the risk factors
for clinical response to opioids for all-age patients with cancer-related pain and presentation
of the paediatric STOP pain study. BMC Cancer. 2018;18(1):568. doi: 10.1186/s12885-018-
4478-3.

29. Bettiol A, Lombardi N, Marconi E, Crescioli G, Bonaiuti R, Maggini V, Gallo E, Mugelli
A, Firenzuoli F, Ravaldi C, Vannacci A. The use of complementary and alternative
medicines during breastfeeding: results from the Herbal supplements in Breastfeeding
InvesTigation (HaBIT) study. Br J Clin Pharmacol. 2018;84(9):2040-2047. doi:
10.1111/bcp.13639.

30. Comoretto RI, Rea F, Lucenteforte E, Mugelli A, Trifirò G, Cascini S, Roberto G,
Chinellato A, Filippelli A, Corrao G; Italian Group for Appropriate Drug prescription in the
Elderly (I-GrADE). Bleeding events attributable to concurrent use of warfarin and other
medications in high-risk elderly: meta-analysis and Italian population-based investigation.
Eur J Clin Pharmacol. 2018;74(8):1061-1070. doi: 10.1007/s00228-018-2467-8.

31. Lombardi N, Crescioli G, Bettiol A, Marconi E, Vitiello A, Bonaiuti R, Calvani AM, Masi
S, Lucenteforte E, Mugelli A, Giovannelli L, Vannacci A. Characterization of serious
adverse drug reactions as cause of emergency department visit in children: a 5-years active
pharmacovigilance study. BMC Pharmacol Toxicol. 2018;19(1):16. doi: 10.1186/s40360-
018-0207-4.

32. Lombardi N, Lucenteforte E, Torrini M, Balzi D, Barchielli A, Mugelli A, Vannacci A.
Ticagrelor-related late-onset dyspnea as cause of emergency department visit: a 3-year
outpatient study. J Cardiovasc Med (Hagerstown). 2018;19(6):284-289. doi:
10.2459/JCM.0000000000000656.

33. Biffi A, Scotti L, Rea F, Lucenteforte E, Chinellato A, Vetrano DL, Vitale C, Agabiti N,
Sultana J, Roberto G, Mugelli A, Corrao G; Italian Group for Appropriate Drug prescription
in the Elderly (I-GrADE). Adherence to Antidepressants and Mortality in Elderly Patients
with Cardiovascular Disease. Clin Drug Investig. 2018;38(7):593-602. doi: 10.1007/s40261-
018-0642-4.

34. Ferrantini C, Pioner JM, Mazzoni L, Gentile F, Tosi B, Rossi A, Belardinelli L, Tesi C,
Palandri C, Matucci R, Cerbai E, Olivotto I, Poggesi C, Mugelli A, Coppini R. Late sodium
current inhibitors to treat exercise-induced obstruction in hypertrophic cardiomyopathy: an
in vitro study in human myocardium. Br J Pharmacol. 2018;175(13):2635-2652. doi:
10.1111/bph.14223.

35. Volpe M, Tocci G, Accettura D, Battistoni A, Bellone S, Bellotti P, Bertolotti M, Borghi
C, Casasco M, Consoli A, Coppini R, Corsini A, Costanzo G, Desideri G, Ferri C, Galanti
G, Giada F, Icardi G, Lombardi N, Modena MG, Modesti PA, Monti G, Mugelli A, Orsi A,
Parati G, Pedretti RF, Perseghin G, Pirro M, Ricotti R, Rizzoni D, Rotella C, Rubattu S,
Salvetti G, Sarto P, Tassinari F, Trimarco B, de Kreutzenberg SV, Volpe R. [Consensus
document and recommendations for the prevention of cardiovascular disease in Italy –
2018]. G Ital Cardiol (Rome). 2018;19(2 Suppl 1):1S-95S. doi: 10.1714/2874.28988.

36. Roberto G, Bartolini C, Rea F, Onder G, Vitale C, Trifirò G, Kirchmayer U, Chinellato A,
Lucenteforte E, Corrao G, Mugelli A, Lapi F, Gini R; Italian Group for Appropriate Drug
prescription in the Elderly (I-GrADE). NSAIDs utilization for musculoskeletal indications
in elderly patients with cerebro/cardiovascular disease. Eur J Clin Pharmacol.
2018;74(5):637-643. doi:10.1007/s00228-018-2411-y.

37. Olivotto I, Camici PG, Merlini PA, Rapezzi C, Patten M, Climent V, Sinagra G, Tomberli
B, Marin F, Ehlermann P, Maier LS, Fornaro A, Jacobshagen C, Ganau A, Moretti L,
Hernandez Madrid A, Coppini R, Reggiardo G, Poggesi C, Fattirolli F, Belardinelli L,
Gensini G, Mugelli A. Efficacy of Ranolazine in Patients With Symptomatic Hypertrophic
Cardiomyopathy: The RESTYLE-HCM Randomized, Double-Blind, Placebo-Controlled
Study. Circ Heart Fail. 2018;11(1):e004124.
doi:10.1161/CIRCHEARTFAILURE.117.004124.

38. Rosati A, Ilvento L, Lucenteforte E, Pugi A, Crescioli G, McGreevy KS, Virgili G,
Mugelli A, De Masi S, Guerrini R. Comparative efficacy of antiepileptic drugs in children
and adolescents: A network meta-analysis. Epilepsia. 2018;59(2):297-314. doi:
10.1111/epi.13981.

39. Calvani M, Cavallini L, Tondo A, Spinelli V, Ricci L, Pasha A, Bruno G, Buonvicino D,
Bigagli E, Vignoli M, Bianchini F, Sartiani L, Lodovici M, Semeraro R, Fontani F, De Logu
F, Dal Monte M, Chiarugi P, Favre C, Filippi L. β3-Adrenoreceptors Control Mitochondrial
Dormancy in Melanoma and Embryonic Stem Cells. Oxid Med Cell Longev.
2018;2018:6816508. doi: 10.1155/2018/6816508.

40. Dini L, Del Lungo M, Resta F, Melchiorre M, Spinelli V, Di Cesare Mannelli L,
Ghelardini C, Laurino A, Sartiani L, Coppini R, Mannaioni G, Cerbai E, Romanelli MN.
Selective Blockade of HCN1/HCN2 Channels as a Potential Pharmacological Strategy
Against Pain. Front Pharmacol. 2018;9:1252. doi:10.3389/fphar.2018.01252.

41. Scardigli M, Müllenbroich C, Margoni E, Cannazzaro S, Crocini C, Ferrantini C, Coppini
R, Yan P, Loew LM, Campione M, Bocchi L, Giulietti D, Cerbai E, Poggesi C, Bub G,
Pavone FS, Sacconi L. Real-time optical manipulation of cardiac conduction in intact hearts.
J Physiol. 2018;596(17):3841-3858. doi:10.1113/JP276283.

42. Aimo A, Vergaro G, Barison A, Maffei S, Borrelli C, Morrone D, Cameli M, Palazzuoli
A, Ambrosio G, Coiro S, Savino K, Cerbai E, Marcucci R, Pedrinelli R, Padeletti L,
Passino C, Emdin M. Sex-related differences in chronic heart failure. Int J Cardiol.
2018;255:145-151. doi:10.1016/j.ijcard.2017.10.068.

43. Scardigli M, Crocini C, Ferrantini C, Gabbrielli T, Silvestri L, Coppini R, Tesi C, RogZielinska EA, Kohl P, Cerbai E, Poggesi C, Pavone FS, Sacconi L. Reply to Entcheva: The
impact of T-tubules on action potential propagation in cardiac tissue. Proc Natl Acad Sci U
S A. 2018;115(4):E562-E563. doi:10.1073/pnas.1720253115.

44. Beltrami M, Palazzuoli A, Padeletti L, Cerbai E, Coiro S, Emdin M, Marcucci R, Morrone
D, Cameli M, Savino K, Pedrinelli R, Ambrosio G; Società Italiana di Cardiologia, Sezione
Regionale Tosco-Umbra. The importance of integrated left atrial evaluation: From
hypertension to heart failure with preserved ejection fraction. Int J Clin Pract. 2018;72(2).
doi: 10.1111/ijcp.13050.

45. Cameli M, Mandoli GE, Ambrosio G, Cerbai E, Coiro S, Emdin M, Marcucci R, Morrone
D, Palazzuoli A, Savino K, Padeletti L, Mondillo S, Pedrinelli R; Società Italiana di
Cardiologia, Sezione Regionale Tosco-Umbra. Arterial hypertension and atrial fibrillation:
standard and advanced echocardiography from diagnosis to prognostication. J Cardiovasc
Med (Hagerstown). 2018;19(2):51-61. doi:10.2459/JCM.0000000000000607.

46. Pedrinelli R, Dell’omo G, Cameli M, Cerbai E, Coiro S, Emdin M, Liga R, Marcucci R,
Morrone D, Palazzuoli A, Savino K, Padeletti L, Ambrosio G; Società Italiana di
Cardiologia, Sezione Regionale Tosco-Umbra. Resistant hypertension: an overview.
Minerva Cardioangiol. 2018;66(3):337-348. doi:10.23736/S0026-4725.17.04495-4.

47. Resta F, Micheli L, Laurino A, Spinelli V, Mello T, Sartiani L, Di Cesare Mannelli L,
Cerbai E, Ghelardini C, Romanelli MN, Mannaioni G, Masi A. Selective HCN1 block as a
strategy to control oxaliplatin-induced neuropathy. Neuropharmacology. 2018;131:403-413.
doi:10.1016/j.neuropharm.2018.01.014.

48. Cimmaruta D, Lombardi N, Borghi C, Rosano G, Rossi F, Mugelli A. Polypill,
hypertension and medication adherence: The solution strategy? Int J Cardiol. 2018 Feb
1;252:181-186. doi: 10.1016/j.ijcard.2017.11.075.

49. Biffi A, Rea F, Scotti L, Mugelli A, Lucenteforte E, Bettiol A, Chinellato A, Onder G,
Vitale C, Agabiti N, Trifirò G, Roberto G, Corrao G; Italian Group for Appropriate Drug
prescription in the Elderly (I-GrADE). Antidepressants and the risk of arrhythmia in elderly
affected by a previous cardiovascular disease: a real-life investigation from Italy. Eur J Clin
Pharmacol. 2018;74(1):119-129. doi: 10.1007/s00228-017-2352-x.

50. Ferrajolo C, Scavone C, Donati M, Bortolami O, Stoppa G, Motola D, Vannacci A,
Mugelli A, Leone R, Capuano A; DILI-IT Study Group. Antidepressant-Induced Acute
Liver Injury: A Case-Control Study in an Italian Inpatient Population. Drug Saf.
2018;41(1):95-102. doi: 10.1007/s40264-017-0583-5.

51. Coppini R, Ferrantini C. NaV1.8: a novel contributor to cardiac arrhythmogenesis in heart
failure. Cardiovasc Res. 2018;114(13):1691-1693. doi: 10.1093/cvr/cvy210.

52. Olivotto I, Coppini R. Channelopathies, cardiac hypertrophy, and the theory of light. Eur
Heart J. 2018;39(31):2908-2910. doi: 10.1093/eurheartj/ehy297.

53. Miceli C, Santin Y, Manzella N, Coppini R, Berti A, Stefani M, Parini A, Mialet-Perez J,
Nediani C. Oleuropein Aglycone Protects against MAO-A-Induced Autophagy Impairment
and Cardiomyocyte Death through Activation of TFEB. Oxid Med Cell Longev. 2018
26;2018:8067592. doi: 10.1155/2018/8067592.

54. Maurizi N, Ammirati E, Coppini R, Morrone A, Olivotto I. Clinical and Molecular
Aspects of Cardiomyopathies: Emerging Therapies and Clinical Trials. Heart Fail Clin.
2018;14(2):161-178. doi: 10.1016/j.hfc.2018.01.001.

55. Scardigli M, Crocini C, Ferrantini C, Gabbrielli T, Silvestri L, Coppini R, Tesi C, RogZielinska EA, Kohl P, Cerbai E, Poggesi C, Pavone FS, Sacconi L. Reply to Entcheva: The
impact of T-tubules on action potential propagation in cardiac tissue. Proc Natl Acad Sci U
S A. 2018;115(4):E562-E563. doi:10.1073/pnas.1720253115.

56. Fornaro A, Olivotto I, Rigacci L, Ciaccheri M, Tomberli B, Ferrantini C, Coppini R,
Girolami F, Mazzarotto F, Chiostri M, Milli M, Marchionni N, Castelli G. Comparison of
long-term outcome in anthracycline-related versus idiopathic dilated cardiomyopathy: a
single centre experience. Eur J Heart Fail. 2018;20(5):898-906. doi: 10.1002/ejhf.1049.

Elenco pubblicazioni anno 2017:
57. Zaglia T, Ceriotti P, Campo A, Borile G, Armani A, Carullo P, Prando V, Coppini R, Vida
V, Stølen TO, Ulrik W, Cerbai E, Stellin G, Faggian G, De Stefani D, Sandri M, Rizzuto R,
Di Lisa F, Pozzan T, Catalucci D, Mongillo M. Content of mitochondrial calcium uniporter
(MCU) in cardiomyocytes is regulated by microRNA-1 in physiologic and pathologic
hypertrophy. Proc Natl Acad Sci U S A. 2017 Oct 24;114(43):E9006-E9015. doi:
10.1073/pnas.1708772114.

58. Lucenteforte E, Lombardi N, Vetrano DL, La Carpia D, Mitrova Z, Kirchmayer U,
Corrao G, Lapi F, Mugelli A, Vannacci A. Inappropriate pharmacological treatment in older
adults affected by cardiovascular disease and other chronic comorbidities: a systematic
literature review to identify potentially inappropriate prescription indicators. Clin Interv
Aging. 2017;12:1761-1778. doi: 10.2147/CIA.S137403.

59. Bettiol A, Lucenteforte E, Vannacci A, Lombardi N, Onder G, Agabiti N, Vitale C, Trifirò
G, Corrao G, Roberto G, Mugelli A, Chinellato A; Italian Group for Appropriate Drug
prescription in the Elderly (I-GrADE). Calcium Channel Blockers in Secondary
Cardiovascular Prevention and Risk of Acute Events: Real-World Evidence from Nested
Case-Control Studies on Italian Hypertensive Elderly. Clin Drug Investig.
2017;37(12):1165-1174. doi: 10.1007/s40261-017-0576-2.

60. Gulizia MM, Colivicchi F, Ricciardi G, Giampaoli S, Maggioni AP, Averna M, Graziani
MS, Ceriotti F, Mugelli A, Rossi F, Medea G, Parretti D, Abrignani MG, Arca M, Perrone
Filardi P, Perticone F, Catapano A, Griffo R, Nardi F, Riccio C, Di Lenarda A, Scherillo M,
Musacchio N, Panno AV, Zito GB, Campanini M, Bolognese L, Faggiano PM, Musumeci
G, Pusineri E, Ciaccio M, Bonora E, Cantelli Forti G, Ruggieri MP, Cricelli C, Romeo F,
Ferrari R, Maseri A. ANMCO/ISS/AMD/ANCE/ARCA/FADOI/GICR-IACPR/SICIISE/SIBioC/SIC/SICOA/SID/SIF/SIMEU/SIMG/SIMI/SISA Joint Consensus Document on
cholesterol and cardiovascular risk: diagnostic-therapeutic pathway in Italy. Eur Heart J
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61. Sartiani L, Mannaioni G, Masi A, Novella Romanelli M, Cerbai E. The
Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels: from Biophysics to
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62. Ferrantini C, Coppini R, Pioner JM, Gentile F, Tosi B, Mazzoni L, Scellini B, Piroddi N,
Laurino A, Santini L, Spinelli V, Sacconi L, De Tombe P, Moore R, Tardiff J, Mugelli A,
Olivotto I, Cerbai E, Tesi C, Poggesi C. Pathogenesis of Hypertrophic Cardiomyopathy is
Mutation Rather Than Disease Specific: A Comparison of the Cardiac Troponin T E163R
and R92Q Mouse Models. J Am Heart Assoc. 2017;6(7). pii: e005407. doi:
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63. Lucenteforte E, Bettiol A, Lombardi N, Mugelli A, Vannacci A. Risk of bone fractures
among users of oral anticoagulants: An administrative database cohort study. Eur J Intern
Med. 2017;44:e30-e31. doi: 10.1016/j.ejim.2017.07.022.

64. Berrino E, Bua S, Mori M, Botta M, Murthy VS, Vijayakumar V, Tamboli Y, Bartolucci
G, Mugelli A, Cerbai E, Supuran CT, Carta F. Novel Sulfamide-Containing Compounds as
Selective Carbonic Anhydrase I Inhibitors. Molecules. 2017;22(7). pii: E1049.
doi:10.3390/molecules22071049.

65. Rea F, Bonassi S, Vitale C, Trifirò G, Cascini S, Roberto G, Chinellato A, Lucenteforte E,
Mugelli A, Corrao G; I-GrADE investigators. Exposure to statins is associated to fracture
risk reduction in elderly people with cardiovascular disease: evidence from the AIFA-IGrADE observational project. Pharmacoepidemiol Drug Saf. 2017;26(7):775-784. doi:
10.1002/pds.4206.

66. Coppini R, Mazzoni L, Ferrantini C, Gentile F, Pioner JM, Laurino A, Santini L, Bargelli
V, Rotellini M, Bartolucci G, Crocini C, Sacconi L, Tesi C, Belardinelli L, Tardiff J,
Mugelli A, Olivotto I, Cerbai E, Poggesi C. Ranolazine Prevents Phenotype Development in
a Mouse Model of Hypertrophic Cardiomyopathy. Circ Heart Fail. 2017;10(3). pii: e003565.
doi:10.1161/CIRCHEARTFAILURE.116.003565.

67. Martella D, Paoli P, Pioner JM, Sacconi L, Coppini R, Santini L, Lulli M, Cerbai E,
Wiersma DS, Poggesi C, Ferrantini C, Parmeggiani C. Liquid Crystalline Networks toward
Regenerative Medicine and Tissue Repair. Small. 2017;13(46).
doi:10.1002/smll.201702677.

68. Di Franco A, Cantini G, Tani A, Coppini R, Zecchi-Orlandini S, Raimondi L, Luconi M,
Mannucci E. Sodium-dependent glucose transporters (SGLT) in human ischemic heart: A
new potential pharmacological target. Int J Cardiol. 2017;243:86-90. doi:
10.1016/j.ijcard.2017.05.032.

69. Di Cesare Mannelli L, Pacini A, Micheli L, Femia AP, Maresca M, Zanardelli M,
Vannacci A, Gallo E, Bilia AR, Caderni G, Firenzuoli F, Mugelli A, Ghelardini C.Astragali
radix: could it be an adjuvant for oxaliplatin-induced neuropathy? Sci Rep. 2017;7:42021.
doi: 10.1038/srep42021.

70. Scardigli M, Crocini C, Ferrantini C, Gabbrielli T, Silvestri L, Coppini R, Tesi C, RogZielinska EA, Kohl P, Cerbai E, Poggesi C, Pavone FS, Sacconi L. Quantitative assessment
of passive electrical properties of the cardiac T-tubular system by FRAP microscopy. Proc
Natl Acad Sci U S A. 2017;114(22):5737-5742. doi: 10.1073/pnas.1702188114.

71. Cappetta D, Esposito G, Coppini R, Piegari E, Russo R, Ciuffreda LP, Rivellino A,
Santini L, Rafaniello C, Scavone C, Rossi F, Berrino L, Urbanek K, De Angelis A. Effects
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72. Crocini C, Ferrantini C, Coppini R, Sacconi L. Electrical defects of the transverse-axial
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73. Castagnoli H, Ferrantini C, Coppini R, Passeri A, Baldini K, Berti V, Cecchi F, Olivotto I,
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Med Mol Imaging. 2016;43(13):2413-2422.

74. Crocini C, Ferrantini C, Coppini R, Scardigli M, Yan P, Loew LM, Smith G, Cerbai E,
Poggesi C, Pavone FS, Sacconi L. Optogenetics design of mechanistically-based stimulation
patterns for cardiac defibrillation. Sci Rep. 2016;6:35628. doi: 10.1038/srep35628.

75. Crocini C, Coppini R, Ferrantini C, Yan P, Loew LM, Poggesi C, Cerbai E, Pavone FS,
Sacconi L. T-Tubular Electrical Defects Contribute to Blunted β-Adrenergic Response in
Heart Failure. Int J Mol Sci. 2016;17(9). pii:E1471. doi: 10.3390/ijms17091471.

76. Coppini R, Simons SHP, Mugelli A, Allegaert K. Clinical research in neonates and
infants: Challenges and perspectives. Pharmacol Res. 2016;108:80-87.
doi:10.1016/j.phrs.2016.04.025.

77. Ammirati E, Contri R, Coppini R, Cecchi F, Frigerio M, Olivotto I. Pharmacological
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Heart Fail. 2016;18(9):1106-18. doi:10.1002/ejhf.541.

78. Olivotto I, Hellawell JL, Farzaneh-Far R, Blair C, Coppini R, Myers J, Belardinelli L,
Maron MS. Novel Approach Targeting the Complex Pathophysiology of Hypertrophic
Cardiomyopathy: The Impact of Late Sodium Current Inhibition on Exercise Capacity in
Subjects with Symptomatic Hypertrophic Cardiomyopathy (LIBERTY-HCM) Trial. Circ
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79. Bongini C, Ferrantini C, Girolami F, Coppini R, Arretini A, Targetti M, Bardi S, Castelli
G, Torricelli F, Cecchi F, Ackerman MJ, Padeletti L, Poggesi C, Olivotto I. Impact of
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80. Ferrantini C, Coppini R, Scellini B, Ferrara C, Pioner JM, Mazzoni L, Priori S, Cerbai E,
Tesi C, Poggesi C. R4496C RyR2 mutation impairs atrial and ventricular contractility. J
Gen Physiol. 2016;147(1):39-52. doi:10.1085/jgp.201511450.

81. Passini E, Mincholé A, Coppini R, Cerbai E, Rodriguez B, Severi S, Bueno-Orovio A.
Mechanisms of pro-arrhythmic abnormalities in ventricular repolarisation and antiarrhythmic therapies in human hypertrophic cardiomyopathy. J Mol Cell Cardiol.
2016;96:72-81. doi:10.1016/j.yjmcc.2015.09.003.

82. Spinelli V, Vona A, Corti F, Diolaiuti L, Zanardelli M, Sartiani L, Failli P. Role of Nitric
Oxide, Nitric Oxide Synthase, Soluble Guanylyl Cyclase, and cGMP-Dependent Protein
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83. Sartiani L, Bucciantini M, Spinelli V, Leri M, Natalello A, Nosi D, Maria Doglia S, Relini
A, Penco A, Giorgetti S, Gerace E, Mannaioni G, Bellotti V, Rigacci S, Cerbai E, Stefani M.
Biochemical and Electrophysiological Modification of Amyloid Transthyretin on
Cardiomyocytes. Biophys J. 2016;111(9):2024-2038. doi: 10.1016/j.bpj.2016.09.010.

84. Lombardi N, Crescioli G, Lucenteforte E, Mugelli A, Vannacci A. Ticagrelor safety
profile in real-life setting of acute coronary syndrome patients. J Chin Med Assoc. 2017
Mar;80(3):183-184. doi: 10.1016/j.jcma.2016.11.003.

85. Vetrano DL, La Carpia D, Grande G, Casucci P, Bacelli T, Bernabei R, Onder G; Italian
Group for Appropriate Drug Prescription in the Elderly (I-GrADE). Anticholinergic
Medication Burden and 5-Year Risk of Hospitalization and Death in Nursing Home Elderly
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doi: 10.1016/j.jamda.2016.07.012.

86. Pignotti MS, Carmela Leo M, Pugi A, De Masi S, Biermann KP, Galli L, Vitali Rosati G,
Buonocore G, Mugelli A, Dani C, Lucenteforte E, Bellini F, Donzelli G; Palivizumab
Consensus Group. Consensus conference on the appropriateness of palivizumab prophylaxis
in respiratory syncytial virus disease. Pediatr Pulmonol. 2016;51(10):1088-1096. doi:
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87. Lombardi N, Crescioli G, Mugelli A, Vannacci A. Ticagrelor recommended over
clopidogrel, only in clinical trials or also in a real-world practice? Expert Rev Cardiovasc
Ther. 2016;14(10):1103-4. doi: 10.1080/14779072.2016.1222902.

88. Gulizia MM, Colivicchi F, Ricciardi G, Giampaoli S, Maggioni AP, Averna M, Graziani
MS, Ceriotti F, Mugelli A, Rossi F, Medea G, Parretti D, Abrignani MG, Arca M, Filardi
PP, Perticone F, Catapano A, Griffo R, Nardi F, Riccio C, Di Lenarda A, Scherillo M,
Musacchio N, Panno AV, Zito GB, Campanini M, Bolognese L, Faggiano PM, Musumeci
G, Pusineri E, Ciaccio M, Bonora E, Cantelli Forti G, Ruggieri MP, Cricelli C, Romeo F,
Ferrari R, Maseri A. [ANMCO/ISS/AMD/ANCE/ARCA/FADOI/GICR-IACPR/SICIGISE/SIBioC/SIC/SICOA/SID/SIF/SIMEU/SIMG/SIMI/SISA Consensus document.
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G Ital Cardiol (Rome). 2016;17(6 Suppl 1):3S-57. doi: 10.1714/2264.24358.

89. Ambrosio G, Komajda M, Mugelli A, Lopez-Sendón J, Tamargo J, Camm J.Management
of stable angina: A commentary on the European Society of Cardiology guidelines. Eur J
Prev Cardiol. 2016;23(13):1401-12. doi:10.1177/2047487316648475. Review.

90. Cameli M, Righini FM, Sparla S, Tacchini D, Dokollari A, Sassi CG, Di Tommaso C,
Curci V, Censini S, Incampo E, Cassano F, Droandi G, Bernazzali S, Focardi M, Ietta F,
Sartiani L, Romagnoli R, Marotta G, Mugelli A, Paulesu L, Sani G,Tanganelli P,
Maccherini M, Mondillo S. First Evidence of Cardiac Stem Cells From the Left Ventricular
Apical Tip in Patients With Left Ventricular Assist Device Implantation. Transplant Proc.
2016;48(2):395-8. doi:10.1016/j.transproceed.2015.12.045.

91. Coppini R, Ferrantini C, Poggesi C, Mugelli A, Olivotto I. [Molecular targets and novel
pharmacological options to prevent myocardial hypertrophic remodeling].G Ital Cardiol
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92. Romanelli MN, Sartiani L, Masi A, Mannaioni G, Manetti D, Mugelli A, Cerbai E. HCN
Channels Modulators: The Need for Selectivity. Curr Top Med Chem. 2016;16(16):1764-
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93. Cerbai E, Sipido KR, Badimon L. Frontiers in Cardiovascular Biology: a forum for
exploratory basic science and translational research from the ESC Council for Basic
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94. Crocini C, Ferrantini C, Scardigli M, Coppini R, Mazzoni L, Lazzeri E, Pioner JM,
Scellini B, Guo A, Song LS, Yan P, Loew LM, Tardiff J, Tesi C, Vanzi F, Cerbai E, Pavone
FS, Sacconi L, Poggesi C. Novel insights on the relationship between T-tubular defects and
contractile dysfunction in a mouse model of hypertrophic cardiomyopathy. J Mol Cell
Cardiol. 2016;91:42-51. doi: 10.1016/j.yjmcc.2015.12.013.

95. Ferrantini C, Coppini R, Scellini B, Ferrara C, Pioner JM, Mazzoni L, Priori S, Cerbai E,
Tesi C, Poggesi C. R4496C RyR2 mutation impairs atrial and ventricular contractility. J
Gen Physiol. 2016;147(1):39-52. doi: 10.1085/jgp.201511450.

96. Passini E, Mincholé A, Coppini R, Cerbai E, Rodriguez B, Severi S, Bueno-Orovio A.
Mechanisms of pro-arrhythmic abnormalities in ventricular repolarisation and antiarrhythmic therapies in human hypertrophic cardiomyopathy. J Mol Cell Cardiol.
2016;96:72-81. doi: 10.1016/j.yjmcc.2015.09.003.

97. Vannacci A, Rafaniello C, Vaccheri A, Arzenton E, Bonaiuti R, Sportiello L, Leone R;
DILI-IT Study Group. Risk of acute and serious liver injury associated to nimesulide and
other NSAIDs: data from drug-induced liver injury case-control study in Italy. Br J Clin
Pharmacol. 2016;82(1):238-48. doi:10.1111/bcp.12938.

98. Flenady V, Wojcieszek AM, Middleton P, Ellwood D, Erwich JJ, Coory M, Khong TY,
Silver RM, Smith GC, Boyle FM, Lawn JE, Blencowe H, Leisher SH, Gross MM, Horey D,
Farrales L, Bloomfield F, McCowan L, Brown SJ, Joseph KS, Zeitlin J, Reinebrant HE,
Ravaldi C, Vannacci A, Cassidy J, Cassidy P, Farquhar C, Wallace E, Siassakos D, Heazell
AE, Storey C, Sadler L, Petersen S, Frøen JF, Goldenberg RL; Lancet Ending Preventable
Stillbirths study group; Lancet Stillbirths In High-Income Countries Investigator Group.
Stillbirths: recall to action in high-income countries. Lancet. 2016;387(10019):691-702. doi:
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