Università di Napoli

Unità di Ricerca: Prof. Bruno Trimarco

Coordinatore:

Sede Universitaria: Università Federico II di Napoli, Dipartimento di Scienze Biomediche Avanzate

Indirizzo: Via Sergio Pansini 5 – 80131 Napoli

Tel: 0817462250
Fax: 0817462256
e-mail: trimarco@unina.it

sito web: www.unina.it
Linee di ricerca:

  1. Cardiopatia ischemica
  2. Cardiomiopatie
  3. Funzione endoteliale
  4. Ipertensione arteriosa
  5. Aggregazione piastrinica
  6. Nutraceutica

Laboratori/strumentazione:

LABORATORI STRUMENTAZIONE
Laboratorio di Biologia cellulare e molecolare

 

Cappa a flusso laminare e cappa chimica; Incubatore CO2 per colture cellulari; Lettore per piastre per fluorescenza, luminescenza e assorbanza (Tecan); Termociclatore per PCR; Termociclatore per Real Time PCR (Applied Byosystem); Sviluppatrice; Refrigeratore (4°C), Refrigeratore (-20°C), Refrigeratore (-80°C);
Laboratorio Radioisotopi (RIA) Semiautomatic Cell Harvester (Skatron); Liquid scintillation analyzer (PerkinElmer); Cobra Gamma Counter
Laboratorio di Istologia Microtomo a slitta (Leica); Stufa per inclusioni in paraffina (Leica); Microscopio a fluorescenza Eclipse E1000 (Nikon) con sistema di acquisizione immagine
Stabulario Dipartimentale e Laboratorio di Sperimentazione Animale Ecocardiografo per piccoli animali con sonda ad alta frequenza (VEVO 770, VisualSonics); Sistema Langerdhorff per la perfusione del cuore isolato; Sistema per acquisizione di parametri emodinamici invasivi nel piccolo animale mediante catetere con microtrasduttore in punta.

Collaborazioni internazionali:

 

  1. Deutsches Herzzentrum, Technische Universität, Munich Germany.
  2. Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA.
  3. Center for Translational Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, USA.
  4. Department of Internal Medicine and Molecular Biology; University of Texas Southwestern Medical Center; Dallas, TX USA.
  5. Department of Cardiology, Swiss Cardiovascular Center Bern, Bern University Hospital, Bern, Switzerland.

 

 

Elenco pubblicazioni del triennio 2016 – 2018:

 

  1. Carnevale D, Perrotta M, Lembo G, Trimarco B. Pathophysiological links among hypertension and alzheimer’s disease. High Blood Pressure and Cardiovascular Prevention. 2016;23:3-7
  2. Cirillo P, Conte S, Pellegrino G, Ziviello F, Barra G, De Palma R, Leonardi A, Trimarco B. Pregnancy-associated plasma protein-a promotes tf procoagulant activity in human endothelial cells by akt–nf-κb axis. Journal of Thrombosis and Thrombolysis. 2016;42:225-232
  3. Contaldi C, Imbriaco M, Alcidi G, Ponsiglione A, Santoro C, Puglia M, Barbuto L, Cuocolo A, Trimarco B, Galderisi M. Assessment of the relationships between left ventricular filling pressures and longitudinal dysfunction with myocardial fibrosis in uncomplicated hypertensive patients. International journal of cardiology. 2016;202:84-86
  4. De Simone G, Izzo R, Losi MA, Stabile E, Rozza F, Canciello G, Mancusi C, Trimarco V, De Luca N, Trimarco B. Depressed myocardial energetic efficiency is associated with increased cardiovascular risk in hypertensive left ventricular hypertrophy. Journal of hypertension. 2016;34:1846-1853
  5. Di Gioia G, Pellicano M, Toth GG, Casselman F, Adjedj J, Van Praet F, Ferrara A, Stockman B, Degrieck I, Bartunek J, Trimarco B, Wijns W, De Bruyne B, Barbato E. Fractional flow reserve-guided revascularization in patients with aortic stenosis. American Journal of Cardiology. 2016;117:1511-1515
  6. Di Gioia G, Pellicano M, Toth GG, Casselman F, Adjedj J, Van Praet F, Stockman B, Degrieck I, Trimarco B, Wijns W, De Bruyne B, Barbato E. Clinical outcome of patients with aortic stenosis and coronary artery disease not treated according to current recommendations. Journal of Cardiovascular Translational Research. 2016;9:145-152
  7. Galderisi M, Trimarco B. Global longitudinal strain: A novel hallmark of cardiac risk in arterial hypertension. Journal of hypertension. 2016;34:1050-1051
  8. Gargiulo G, Capodanno D, Sannino A, Barbanti M, Perrino C, Capranzano P, Stabile E, Indolfi C, Trimarco B, Tamburino C, Esposito G. New-onset atrial fibrillation and increased mortality after transcatheter aortic valve implantation: A causal or spurious association? International journal of cardiology. 2016;203:264-266
  9. Giamundo A, Canciello G, Rapacciuolo A, Musella F, Savarese G, Strisciuglio T, Stabile E, Izzo R, Trimarco B, Losi MA. Comparison of linear versus cubic assessment of left atrial size in the prediction of atrial fibrillation development in hypertrophic cardiomyopathy. International journal of cardiology. 2016;212:198-200
  10. Ilardi F, Santoro C, Cirillo P, Esposito G, Trimarco B, Galderisi M. Quantitative detection of inducible ischemia during dobutamine stress by speckle tracking echocardiography: A dream comes true. International journal of cardiology. 2016;220:357-359
  11. Johnson NP, Jeremias A, Zimmermann FM, Adjedj J, Witt N, Hennigan B, Koo BK, Maehara A, Matsumura M, Barbato E, Esposito G, Trimarco B, Rioufol G, Park SJ, Yang HM, Baptista SB, Chrysant GS, Leone AM, Berry C, De Bruyne B, Gould KL, Kirkeeide RL, Oldroyd KG, Pijls NHJ, Fearon WF. Continuum of vasodilator stress from rest to contrast medium to adenosine hyperemia for fractional flow reserve assessment. JACC: Cardiovascular Interventions. 2016;9:757-767
  12. Lembo M, Esposito R, Lo Iudice F, Santoro C, Izzo R, De Luca N, Trimarco B, De Simone G, Galderisi M. Impact of pulse pressure on left ventricular global longitudinal strain in normotensive and newly diagnosed, untreated hypertensive patients. Journal of hypertension. 2016;34:1201-1207
  13. Lønnebakken MT, Izzo R, Mancusi C, Losi MA, Stabile E, Rozza F, Gerdts E, Trimarco B, De Luca N, De Simone G. Aortic root dimension and arterial stiffness in arterial hypertension: The campania salute network. Journal of hypertension. 2016;34:1109-1114
  14. Mangiacapra F, Conte M, Demartini C, Muller O, Delrue L, Dierickx K, Di Sciascio G, Trimarco B, De Bruyne B, Wijns W, Bartunek J, Barbato E. Relationship of asymmetric dimethylarginine (adma) with extent and functional severity of coronary atherosclerosis. International journal of cardiology. 2016;220:629-633
  15. Meccariello A, Buono F, Verrengia E, Orefice G, Grieco F, Romeo F, Trimarco B, Morisco C. Microalbuminuria predicts the recurrence of cardiovascular events in patients with essential hypertension. Journal of hypertension. 2016;34:646-653
  16. Perrino C, Imbriaco M, Magliulo F, Ponsiglione A, Puglia M, Stabile E, Avvedimento M, Esposito G, Perrone Filardi P, Cuocolo A, Galderisi M, Trimarco B. Tako-tsubo syndrome and myocarditis: Two sides of the same coin or same side for two different coins? International journal of cardiology. 2016;203:40-42
  17. Rengo G, Pagano G, Vitale DF, Formisano R, Komici K, Petraglia L, Parisi V, Femminella GD, de Lucia C, Paolillo S, Cannavo A, Attena E, Pellegrino T, Dellegrottaglie S, Memmi A, Trimarco B, Cuocolo A, Filardi PP, Leosco D, Ferrara N. Impact of aging on cardiac sympathetic innervation measured by 123i-mibg imaging in patients with systolic heart failure. European Journal of Nuclear Medicine and Molecular Imaging. 2016;43:2392-2400
  18. Savarese G, D’Amore C, Federici M, De Martino F, Dellegrottaglie S, Marciano C, Ferrazzano F, Losco T, Lund LH, Trimarco B, Rosano GMC, Perrone-Filardi P. Effects of dipeptidyl peptidase 4 inhibitors and sodium-glucose linked cotransporter-2 inhibitors on cardiovascular events in patients with type 2 diabetes mellitus: A meta-analysis. International journal of cardiology. 2016;220:595-601
  19. Scala O, Paolillo S, Formisano R, Pellegrino T, Rengo G, Gargiulo P, De Michele F, Starace A, Rapacciuolo A, Parisi V, Prastaro M, Piscopo V, Dellegrottaglie S, Bruzzese D, De Martino F, Parente A, Leosco D, Trimarco B, Cuocolo A, Perrone-Filardi P. Sleep-disordered breathing, impaired cardiac adrenergic innervation and prognosis in heart failure. Heart. 2016;102:1813-1819
  20. Schiano-Lomoriello V, Galderisi M, Mele D, Esposito R, Cerciello G, Buonauro A, Della Pepa R, Picardi M, Catalano L, Trimarco B, Pane F. Longitudinal strain of left ventricular basal segments and e/e′ ratio differentiate primary cardiac amyloidosis at presentation from hypertensive hypertrophy: An automated function imaging study. Echocardiography. 2016;33:1335-1343
  21. Schiattarella GG, Cattaneo F, Pironti G, Magliulo F, Carotenuto G, Pirozzi M, Polishchuk R, Borzacchiello D, Paolillo R, Oliveti M, Boccella N, Avvedimento M, Sepe M, Gargiulo G, Lombardi A, Busiello RA, Trimarco B, Esposito G, Feliciello A, Perrino C. Correction: Akap1 deficiency promotes mitochondrial aberrations and exacerbates cardiac injury following permanent coronary ligation via enhanced mitophagy and apoptosis. PLoS ONE. 2016;11
  22. Schiattarella GG, Cattaneo F, Pironti G, Magliulo F, Carotenuto G, Pirozzi M, Polishchuk R, Borzacchiello D, Paolillo R, Oliveti M, Boccella N, Avvedimento M, Sepe M, Lombardi A, Busiello RA, Trimarco B, Esposito G, Feliciello A, Perrino C. Akap1 deficiency promotes mitochondrial aberrations and exacerbates cardiac injury following permanent coronary ligation via enhanced mitophagy and apoptosis. PLoS ONE. 2016;11
  23. Schiattarella GG, Sannino A, Toscano E, Cattaneo F, Trimarco B, Esposito G, Perrino C. Cardiovascular effects of histone deacetylase inhibitors epigenetic therapies: Systematic review of 62 studies and new hypotheses for future research. International journal of cardiology. 2016;219:396-403
  24. Spinelli L, Pellegrino T, Pisani A, Giudice CA, Riccio E, Imbriaco M, Salvatore M, Trimarco B, Cuocolo A. Relationship between left ventricular diastolic function and myocardial sympathetic denervation measured by123i-meta-iodobenzylguanidine imaging in anderson-fabry disease. European Journal of Nuclear Medicine and Molecular Imaging. 2016;43:729-739
  25. Stabile E, Izzo R, Rozza F, Losi MA, Coscioni E, Trimarco B. Real data on effectiveness, tolerability and safety of new oral anticoagulant agents: Focus on dabigatran. High Blood Pressure and Cardiovascular Prevention. 2016;23:115-122
  26. Stabile E, Salemme L, Ferrone M, Arcari A, Cioppa A, Popusoi G, Pucciarelli A, Trimarco B, Esposito G, Tesorio T. Abluminal biodegradable polymer-based biolimus a9-eluting stent for the treatment of infrapopliteal arteries in critical limb ischemia: Long-term follow-up. International journal of cardiology. 2016;202:98-99
  27. Caggiano R, Cattaneo F, Moltedo O, Esposito G, Perrino C, Trimarco B, Ammendola R, Faraonio R. Mir-128 is implicated in stress responses by targeting mafg in skeletal muscle cells. Oxidative Medicine and Cellular Longevity. 2017;2017
  28. Senni M, Trimarco B, Emdin M, De Biase L. Sacubitril/valsartan, a new and effective treatment of heart failure with reduced ejection fraction. Giornale Italiano di Cardiologia. 2017;18:S3-S11
  29. De Rosa S, Eposito F, Carella C, Strangio A, Ammirati G, Sabatino J, Abbate FG, Iaconetti C, Liguori V, Pergola V, Polimeni A, Coletta S, Gareri C, Trimarco B, Stabile G, Curcio A, Indolfi C, Rapacciuolo A. Transcoronary concentration gradients of circulating micrornas in heart failure. European Journal of Heart Failure. 2018